Exposure to zinc oxide nanoparticles (ZnO-NPs) induces cardiovascular toxicity and exacerbates pathogenesis – Role of oxidative stress and MAPK signaling

The precise toxico-pathogenic effects of zinc oxide nanoparticles (ZnO-NPs) on the cardiovascular system under normal and cardiovascular disease (CVD) risk factor milieu are unclear. In this study, we have investigated the dose-dependent effects of ZnO-NPs on developing chicken embryo and cell cultu...

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Veröffentlicht in:	Chemico-biological interactions 2022-01, Vol.351, p.109719-109719, Article 109719
Hauptverfasser:	Nagarajan, Manigandan, Maadurshni, Gobichettipalayam Balasubramaniam, Tharani, Ganeshmurthy Kanniamal, Udhayakumar, Inbamani, Kumar, Gayathri, Mani, Krishna Priya, Sivasubramanian, Jeganathan, Manivannan, Jeganathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cardiomegaly - chemically induced Cardiomegaly - metabolism Cardiotoxicity Cardiotoxins - toxicity Cardiovascular Chickens Cytotoxicity Embryo, Nonmammalian - drug effects Heart - drug effects Human Umbilical Vein Endothelial Cells Humans MAP Kinase Signaling System - drug effects Metal Nanoparticles - toxicity Mitochondria - drug effects Nanotoxicity Oxidative stress Oxidative Stress - drug effects Rats Zinc Oxide - toxicity
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