In Situ Monitoring of Protein Unfolding/Structural States under Cold High-Pressure Stress

Biopharmaceutical formulations may be compromised by freezing, which has been attributed to protein conformational changes at a low temperature, and adsorption to ice–liquid interfaces. However, direct measurements of unfolding/conformational changes in sub-0 °C environments are limited because at a...

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Veröffentlicht in:	Molecular pharmaceutics 2021-12, Vol.18 (12), p.4415-4427
Hauptverfasser:	Gomes, Diana C, Teixeira, Susana C. M, Leão, Juscelino B, Razinkov, Vladimir I, Qi, Wei, Rodrigues, Miguel A, Roberts, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Chymotrypsinogen - chemistry Cold Temperature Fluorescence Neutron Diffraction Pressure Protein Conformation Protein Folding Protein Stability Scattering, Small Angle Thermodynamics
Online-Zugang:	Volltext
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