A reproductive and developmental toxicity screening study of 1,3-butadiene in Sprague-Dawley rats

1,3 Butadiene (BD) is an industrial intermediate used primarily in product manufacturing with the greatest exposure potential via inhalation. BD was evaluated for reproductive and developmental effects in a Good Laboratory Practice (GLP)-compliant, extended OECD 421 guideline study (completed 2003)....

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2021-12, Vol.127, p.105066-105066, Article 105066
Hauptverfasser:	Marty, M. Sue, Erraguntla, Neeraja, North, Colin, Barranco, Wade T., Kirman, Christopher R., Cagen, Stuart, Rushton, Erik K., Shen, Hua, Koehler, Matthew W., Budinsky, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3 butadiene Animals Body Weight - drug effects Butadienes - pharmacology Dose-Response Relationship, Drug Female Inhalation Exposure Litter Size - drug effects Male No-Observed-Adverse-Effect Level OECD 421 Ovary - drug effects Rats Reproduction - drug effects Reproductive toxicity Species Specificity Spermatozoa - drug effects Testis - drug effects Weight Gain - drug effects
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