Characterization and functional role of rapid- and slow-activating delayed rectifier K+ currents in atrioventricular node cells of guinea pigs

The atrioventricular (AV) node is the only conduction pathway where electrical impulse can pass from atria to ventricles and exhibits spontaneous automaticity. This study examined the function of the rapid- and slow-activating delayed rectifier K + currents ( I Kr and I Ks ) in the regulation of AV...

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Veröffentlicht in:	Pflügers Archiv 2021-12, Vol.473 (12), p.1885-1898
Hauptverfasser:	Yuasa, Mayumi, Kojima, Akiko, Mi, Xinya, Ding, Wei-Guang, Omatsu-Kanbe, Mariko, Kitagawa, Hirotoshi, Matsuura, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Action Potentials - physiology Adrenergic beta-Agonists - pharmacology Adrenergic receptors Animals Atrioventricular Node - drug effects Atrioventricular Node - metabolism Automation Biomedical and Life Sciences Biomedicine Cell Biology Cell membranes Female Firing rate Guinea Pigs Heart Atria - drug effects Heart Atria - metabolism Heart Ventricles - drug effects Heart Ventricles - metabolism Human Physiology Immunocytochemistry Ion Channels Isoproterenol Isoproterenol - pharmacology Molecular Medicine Myocardium - metabolism Neurosciences Patch-Clamp Techniques - methods Potassium Potassium Channels - metabolism Potassium currents Receptors Receptors and Transporters Voltage
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