A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial
The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into a...
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| Veröffentlicht in: | Acta medica Okayama 2021-10, Vol.75 (5), p.663-667 |
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| creator | Sadahira, Takuya Maruyama, Yuki Hiyama, Yoshiki Kitano, Hiroyuki Yamada, Hiroki Goto, Takayuki Kondo, Tsubasa Shigemura, Katsumi Mitsui, Yosuke Iwata, Takehiro Edamura, Kohei Araki, Motoo Watanabe, Masami Takenaka, Tadasu Teishima, Jun Miyata, Yasuyoshi Ishikawa, Kiyohito Takaoka, Ei-Ichiro Miyazaki, Jun Takahashi, Satoshi Masumori, Naoya Kiyota, Hiroshi Fujisawa, Masato Yamamoto, Shingo Sakuma, Takafumi Kusumi, Norihiro Ichikawa, Takaharu Watanabe, Toyohiko Nasu, Yoshitsugu Tsugawa, Masaya Nasu, Yasutomo Wada, Koichiro |
| description | The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants. |
| doi_str_mv | 10.18926/amo/62782 |
| format | Article |
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Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.</abstract><cop>Japan</cop><pmid>34703052</pmid><doi>10.18926/amo/62782</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - therapeutic use Bacterial Infections - diagnosis Bacterial Infections - drug therapy Bacterial Infections - microbiology Humans Male Multicenter Studies as Topic Prostatic Diseases - drug therapy Prostatic Diseases - microbiology Prostatic Diseases - pathology Randomized Controlled Trials as Topic |
| title | A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial |
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