Bacterial cellulose adhesive composites for oral cavity applications

Topical approaches to oral diseases require frequent dosing due to limited retention time. A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based b...

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Veröffentlicht in:Carbohydrate polymers 2021-11, Vol.274, p.118403-118403, Article 118403
Hauptverfasser: Singh, Juhi, Tan, Nigel C.S., Mahadevaswamy, Usha Rani, Chanchareonsook, Nattharee, Steele, Terry W.J., Lim, Sierin
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container_end_page 118403
container_issue
container_start_page 118403
container_title Carbohydrate polymers
container_volume 274
creator Singh, Juhi
Tan, Nigel C.S.
Mahadevaswamy, Usha Rani
Chanchareonsook, Nattharee
Steele, Terry W.J.
Lim, Sierin
description Topical approaches to oral diseases require frequent dosing due to limited retention time. A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives (PDz) are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 h in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5–5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity. [Display omitted] •Bacterial cellulose (BC) physically modified into a light-activated bioadhesive•Cellulose composites evaluated for adhesive properties to wet mucosal tissues•Structure property evaluation-BC film type, joules light dose, hydration state•Composites exhibited 2–5 times higher adhesion strength than existing formulations•Composites achieved retention times of 2–7 days in harsh, dynamic environments
doi_str_mv 10.1016/j.carbpol.2021.118403
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A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives (PDz) are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 h in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5–5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity. 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subjects Acetobacteraceae - metabolism
Adhesives - chemistry
Bacterial cellulose
Bioadhesives
Cellulose - chemistry
Drug Delivery Systems - methods
Mouth - chemistry
Mouth - microbiology
Mucoadhesives
Oral patch
Pharmaceutical Preparations, Dental - administration & dosage
Photocuring
title Bacterial cellulose adhesive composites for oral cavity applications
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