Construction and immunogenicity of a T cell epitope-based subunit vaccine candidate against Mycobacterium tuberculosis

•This study is the first to design a tuberculosis vaccine based on T cell epitopes.•T cell epitope-based subunit vaccinestimulated strong Th1-type cellular immune response.•The used approach could be useful against latent TB. Despite antibiotic treatment and Bacille Calmette-Guérin (BCG) vaccination...

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Veröffentlicht in:	Vaccine 2021-11, Vol.39 (47), p.6860-6865
Hauptverfasser:	Fan, Xueting, Li, Xiaoyan, Wan, Kanglin, Zhao, Xiuqin, Deng, Yunli, Chen, Zixin, Luan, Xiuli, Lu, Shuangshuang, Liu, Haican
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antibiotics Antibody response Antigens Antigens, Bacterial - genetics Bacterial Proteins - genetics BCG Vaccine CD4 antigen Cell proliferation Cloning Cytokines Developing countries Disease control Epitopes Epitopes, T-Lymphocyte Flow cytometry Homology IgG antibody Immune response Immune response (cell-mediated) Immune system Immunodominance Immunogenicity Immunoglobulin G Inclusion bodies LDCs Lymphocytes Lymphocytes T Mice Mycobacterium bovis Mycobacterium tuberculosis Proteins PstS1 Public health T cell epitopes TB vaccine Tuberculosis Tuberculosis Vaccines Tumor necrosis factor-TNF Vaccination Vaccines Vaccines, Subunit
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