Characteristics of immune checkpoint regulators and potential role of soluble TIM-3 and LAG-3 in male patients with alcohol-associated liver disease

The involvement of immune checkpoint regulators (ICs) in alcohol-associated liver diseases (ALDs) is still largely unknown. Here, we analyzed the levels of 16 soluble ICs (sICs) in male patients with ALD to determine their clinical significance. The 16 sICs were measured using a luminex-based multip...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2022-02, Vol.98, p.9-17
Hauptverfasser:	Fadriquela, Ailyn, Kim, Cheol-Su, Lee, Kyu-Jae, Kang, Seong Hee, Lee, Jong-Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alcohol Alcohol use alcohol-associated liver disease Alcoholism Antigens, CD - metabolism biomarker Biomarkers Blood Blood platelets CD223 antigen CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes Clinical significance Factor analysis Fibrosis Flow cytometry Hepatitis Hepatitis A Virus Cellular Receptor 2 - metabolism Humans Immune checkpoint Immune Checkpoint Proteins - metabolism immune checkpoint regulator Immunotherapy Laboratories LAG-3 Ligands Liver Cirrhosis Liver diseases Liver Diseases, Alcoholic Lymphocytes Lymphocytes T Male Males Mens health Natural killer cells Pathogenesis Patients PD-1 protein Proteins Regression analysis Risk assessment Risk factors Software Therapeutic targets TIM-3
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