Mitochondria govern histone acetylation in colorectal cancer

Cancer cells have an altered metabolic state that supports their growth, for example, aerobic glycolysis, known as the Warburg effect. Colorectal cancer cells have been reported to exhibit the Warburg effect and mainly rely on glycolysis for progression and have dysfunctional mitochondria. So far, h...

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Veröffentlicht in:	The Journal of pathology 2022-02, Vol.256 (2), p.164-173
Hauptverfasser:	Ohshima, Kenji, Oi, Ryo, Nojima, Satoshi, Morii, Eiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology anchorage‐independent growth Cell Proliferation Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Epigenesis, Genetic Gene Expression Regulation, Neoplastic Glycolysis H3K27ac HCT116 Cells histone acetylation Histone H3 Histones Histones - metabolism Humans Immunoblotting Immunohistochemistry Lysine Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Mucosa Protein Processing, Post-Translational Warburg Effect, Oncologic
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