Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers
Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater. The chitosan-based composites were characteriz...
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| Veröffentlicht in: | Marine pollution bulletin 2021-12, Vol.173 (Pt B), p.113068-113068, Article 113068 |
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| container_end_page | 113068 |
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| container_issue | Pt B |
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| container_title | Marine pollution bulletin |
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| creator | Li, Fang Lian, Ziru Song, Chunxia Ge, Changzi |
| description | Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater. The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses. The swelling behavior, adsorption capability, and selectivity for FF were investigated. The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF. The release studies of MIPs as drug delivery carriers were evaluated in natural seawater. The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation. The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
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•Novel molecularly imprinted polymers for florfenicol (FF-MIPs) were prepared.•The chitosan-based composites showed remarkable drug loading capacity.•The MIPs were applied as eco-friendly drug delivery carriers of targeted FF.•The MIPs exhibited a two-phase sustained release of FF in natural seawater. |
| doi_str_mv | 10.1016/j.marpolbul.2021.113068 |
| format | Article |
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[Display omitted]
•Novel molecularly imprinted polymers for florfenicol (FF-MIPs) were prepared.•The chitosan-based composites showed remarkable drug loading capacity.•The MIPs were applied as eco-friendly drug delivery carriers of targeted FF.•The MIPs exhibited a two-phase sustained release of FF in natural seawater.</description><identifier>ISSN: 0025-326X</identifier><identifier>EISSN: 1879-3363</identifier><identifier>DOI: 10.1016/j.marpolbul.2021.113068</identifier><identifier>PMID: 34689077</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adsorption ; Analytical methods ; Antibiotics ; Aquaculture ; Chemical analysis ; Chitosan ; Chitosan-based ; Controlled release ; Drug Carriers ; Drug delivery ; Drug delivery systems ; Drugs ; Electron microscopy ; Florfenicol ; Fourier transforms ; Imprinted polymers ; Imprinting ; Infrared analysis ; Infrared spectroscopy ; Kinetic equations ; Microspheres ; Molecular Imprinting ; Polymers ; Saturation ; Scanning electron microscopy ; Seawater ; Selectivity ; Substrates ; Surface imprinting ; Sustained release ; Thiamphenicol - analogs & derivatives ; Water analysis</subject><ispartof>Marine pollution bulletin, 2021-12, Vol.173 (Pt B), p.113068-113068, Article 113068</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Dec 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-ddbb83a88c25891681c733b42cc6dac905c84ca962bd5ebc4b928a02b3c83cfb3</citedby><cites>FETCH-LOGICAL-c399t-ddbb83a88c25891681c733b42cc6dac905c84ca962bd5ebc4b928a02b3c83cfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0025326X21011024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34689077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Lian, Ziru</creatorcontrib><creatorcontrib>Song, Chunxia</creatorcontrib><creatorcontrib>Ge, Changzi</creatorcontrib><title>Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers</title><title>Marine pollution bulletin</title><addtitle>Mar Pollut Bull</addtitle><description>Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater. The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses. The swelling behavior, adsorption capability, and selectivity for FF were investigated. The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF. The release studies of MIPs as drug delivery carriers were evaluated in natural seawater. The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation. The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
[Display omitted]
•Novel molecularly imprinted polymers for florfenicol (FF-MIPs) were prepared.•The chitosan-based composites showed remarkable drug loading capacity.•The MIPs were applied as eco-friendly drug delivery carriers of targeted FF.•The MIPs exhibited a two-phase sustained release of FF in natural seawater.</description><subject>Adsorption</subject><subject>Analytical methods</subject><subject>Antibiotics</subject><subject>Aquaculture</subject><subject>Chemical analysis</subject><subject>Chitosan</subject><subject>Chitosan-based</subject><subject>Controlled release</subject><subject>Drug Carriers</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Electron microscopy</subject><subject>Florfenicol</subject><subject>Fourier transforms</subject><subject>Imprinted polymers</subject><subject>Imprinting</subject><subject>Infrared analysis</subject><subject>Infrared spectroscopy</subject><subject>Kinetic equations</subject><subject>Microspheres</subject><subject>Molecular Imprinting</subject><subject>Polymers</subject><subject>Saturation</subject><subject>Scanning electron microscopy</subject><subject>Seawater</subject><subject>Selectivity</subject><subject>Substrates</subject><subject>Surface imprinting</subject><subject>Sustained release</subject><subject>Thiamphenicol - analogs & derivatives</subject><subject>Water analysis</subject><issn>0025-326X</issn><issn>1879-3363</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9rb6FzTgxs1c8zGTSZalVC0UBFFwF5IzZ2yumck1mVH6781waxduXAXCc97kvA8hrznbc8bVu8N-cvmYol_jXjDB95xLpvQTsuO6N42USj4lO8ZE10ihvp2R81IOjLFe9Pw5OZOt0ob1_Y78-IwRXUGaRjrGlEecA6RIw0wLut9uwUzXEubvFO7CkoqbG1_xgU4pIqzR5XhPw3TMYV622wA5leMdZizUFTrktU66nAPm8oI8G10s-PLhvCBf319_ufrY3H76cHN1eduANGZphsF7LZ3WIDptuNIceil9KwDU4MCwDnQLzijhhw49tN4I7ZjwErSE0csL8vaUe8zp54plsVMogDG6GdNabI3tzNaFruibf9BDWvNcf2eFEpK1QitTqf5EbcuVjKOt-1YB95Yzu_mwB_vow24-7MlHnXz1kL_6CYfHub8CKnB5ArAW8qu2ZAsEnAGHkBEWO6Tw30f-AOqAopo</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Li, Fang</creator><creator>Lian, Ziru</creator><creator>Song, Chunxia</creator><creator>Ge, Changzi</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7T7</scope><scope>7TN</scope><scope>7TV</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers</title><author>Li, Fang ; Lian, Ziru ; Song, Chunxia ; Ge, Changzi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-ddbb83a88c25891681c733b42cc6dac905c84ca962bd5ebc4b928a02b3c83cfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adsorption</topic><topic>Analytical methods</topic><topic>Antibiotics</topic><topic>Aquaculture</topic><topic>Chemical analysis</topic><topic>Chitosan</topic><topic>Chitosan-based</topic><topic>Controlled release</topic><topic>Drug Carriers</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Electron microscopy</topic><topic>Florfenicol</topic><topic>Fourier transforms</topic><topic>Imprinted polymers</topic><topic>Imprinting</topic><topic>Infrared analysis</topic><topic>Infrared spectroscopy</topic><topic>Kinetic equations</topic><topic>Microspheres</topic><topic>Molecular Imprinting</topic><topic>Polymers</topic><topic>Saturation</topic><topic>Scanning electron microscopy</topic><topic>Seawater</topic><topic>Selectivity</topic><topic>Substrates</topic><topic>Surface imprinting</topic><topic>Sustained release</topic><topic>Thiamphenicol - analogs & derivatives</topic><topic>Water analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Lian, Ziru</creatorcontrib><creatorcontrib>Song, Chunxia</creatorcontrib><creatorcontrib>Ge, Changzi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oceanic Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Marine pollution bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Fang</au><au>Lian, Ziru</au><au>Song, Chunxia</au><au>Ge, Changzi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers</atitle><jtitle>Marine pollution bulletin</jtitle><addtitle>Mar Pollut Bull</addtitle><date>2021-12</date><risdate>2021</risdate><volume>173</volume><issue>Pt B</issue><spage>113068</spage><epage>113068</epage><pages>113068-113068</pages><artnum>113068</artnum><issn>0025-326X</issn><eissn>1879-3363</eissn><abstract>Novel molecularly imprinted polymer (MIP) microspheres using functionalized chitosan as eco-friendly substrates were prepared by surface imprinting method and applied as drug delivery carriers to provide extended-release of florfenicol (FF) in seawater. The chitosan-based composites were characterized by scanning electron microscopy and Fourier transforms infrared spectroscopy analyses. The swelling behavior, adsorption capability, and selectivity for FF were investigated. The results show that the MIPs possessed high drug loading saturation capacity and specific recognition affinity for FF. The release studies of MIPs as drug delivery carriers were evaluated in natural seawater. The microspheres exhibited slow sustained release profiles of FF and the release behavior conformed to the first-order kinetic equation. The imprinted microspheres as drug delivery devices would be a promising application for improving the efficacy of the antibiotic without exposing the ecological system to excess FF in aquaculture.
[Display omitted]
•Novel molecularly imprinted polymers for florfenicol (FF-MIPs) were prepared.•The chitosan-based composites showed remarkable drug loading capacity.•The MIPs were applied as eco-friendly drug delivery carriers of targeted FF.•The MIPs exhibited a two-phase sustained release of FF in natural seawater.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34689077</pmid><doi>10.1016/j.marpolbul.2021.113068</doi><tpages>1</tpages></addata></record> |
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| ispartof | Marine pollution bulletin, 2021-12, Vol.173 (Pt B), p.113068-113068, Article 113068 |
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| subjects | Adsorption Analytical methods Antibiotics Aquaculture Chemical analysis Chitosan Chitosan-based Controlled release Drug Carriers Drug delivery Drug delivery systems Drugs Electron microscopy Florfenicol Fourier transforms Imprinted polymers Imprinting Infrared analysis Infrared spectroscopy Kinetic equations Microspheres Molecular Imprinting Polymers Saturation Scanning electron microscopy Seawater Selectivity Substrates Surface imprinting Sustained release Thiamphenicol - analogs & derivatives Water analysis |
| title | Release of florfenicol in seawater using chitosan-based molecularly imprinted microspheres as drug carriers |
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