Low glycaemic diets alter lipid metabolism to influence tumour growth

Dietary interventions can change metabolite levels in the tumour microenvironment, which might then affect cancer cell metabolism to alter tumour growth 1 – 5 . Although caloric restriction (CR) and a ketogenic diet (KD) are often thought to limit tumour progression by lowering blood glucose and ins...

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Veröffentlicht in:	Nature (London) 2021-11, Vol.599 (7884), p.302-307
Hauptverfasser:	Lien, Evan C., Westermark, Anna M., Zhang, Yin, Yuan, Chen, Li, Zhaoqi, Lau, Allison N., Sapp, Kiera M., Wolpin, Brian M., Vander Heiden, Matthew G.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 631/45/287/1183 631/45/320 631/67/2327 64/60 82/29 82/58 96/1 Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Allografts Animals Availability Blood glucose Blood Glucose - metabolism Body fat Caloric Restriction Cancer Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell growth Cell Line, Tumor Cell Proliferation Desaturase Desaturation Dextrose Diet Diet therapy Diet, Carbohydrate-Restricted Diet, Ketogenic Dietary restrictions Extracellular Fluid - chemistry Fatty acids Fatty Acids - metabolism Fatty Acids, Unsaturated - metabolism Female Glucose Health aspects High fat diet Humanities and Social Sciences Insulin Ketogenesis Lipid metabolism Lipid Metabolism - drug effects Lipids Low carbohydrate diet Male Metabolism Metabolites Mice Mice, Inbred C57BL Microenvironments multidisciplinary Neoplasm Transplantation Neoplasms - metabolism Neoplasms - pathology Nutrient availability Nutrient deficiency Nutrients - analysis Nutrients - blood Physiological aspects Plasma Ratios Science Science (multidisciplinary) Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - metabolism Tumor microenvironment Tumor Microenvironment - drug effects Tumors
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