The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis

Dysregulation of Notch signaling has been implicated in cellular transformation and tumorigenesis in a variety of cancers while potential roles of MIB1, an E3 ubiquitin ligase required for efficient Notch activation, remains to be investigated. We analyzed MIB1 expression levels in tumor samples and...

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Veröffentlicht in:	Molecular cancer research 2022-02, Vol.20 (2), p.253-264
Hauptverfasser:	Wang, Haiyun, Huang, Qiuling, Xia, Jianhong, Cheng, Shan, Pei, Duanqing, Zhang, Xiaofei, Shu, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ferroptosis - genetics Humans Lung Neoplasms - genetics Mice Mice, Knockout NF-E2-Related Factor 2 - genetics Transfection Ubiquitin-Protein Ligases - metabolism Zebrafish
Online-Zugang:	Volltext
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