Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents
•Pediatric reference intervals were determined for 32 Siemens Atellica® CH assays.•Of 32 parameters, 26 required age partitioning and 18 required sex partitioning.•Assay reference distributions mirrored those on other systems with few exceptions. Pediatric reference intervals are essential for test...
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Veröffentlicht in: | Clinical biochemistry 2022-01, Vol.99, p.69-77 |
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description | •Pediatric reference intervals were determined for 32 Siemens Atellica® CH assays.•Of 32 parameters, 26 required age partitioning and 18 required sex partitioning.•Assay reference distributions mirrored those on other systems with few exceptions.
Pediatric reference intervals are essential for test interpretation. With development of newer analytical systems, de novo reference interval establishment is of necessary importance. In the current study, pediatric reference intervals were determined for 32 analytes using Siemens Healthineers Atellica® CH assays in the CALIPER cohort of healthy children and adolescents.
Approximately 600 healthy children and adolescents were recruited with informed consent and collected serum samples were analyzed on the Siemens Healthineers Atellica® CH platform. Assays studied included enzymes, proteins, lipids, electrolytes, and additional markers Reference intervals were established according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Of the 32 parameters, 26 required age partitioning and 18 required sex partitioning. Reference value distributions included consistent increases, decreases, and dynamic variation across the age continuum. Chloride, LDL cholesterol, glucose, lipase, sodium, and triglyceride demonstrated no age or sex-specific differences.
The current study expands the clinical utility of the CALIPER database to include 32 Siemens Atellica® chemistry assays. Reference value distributions for Siemens assays mirrored those observed on other comparable assays/systems with few exceptions (e.g. lipase, direct and total bilirubin). These finding support the robustness of previously derived reference intervals in the CALIPER cohort and other global cohorts. |
doi_str_mv | 10.1016/j.clinbiochem.2021.10.006 |
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Pediatric reference intervals are essential for test interpretation. With development of newer analytical systems, de novo reference interval establishment is of necessary importance. In the current study, pediatric reference intervals were determined for 32 analytes using Siemens Healthineers Atellica® CH assays in the CALIPER cohort of healthy children and adolescents.
Approximately 600 healthy children and adolescents were recruited with informed consent and collected serum samples were analyzed on the Siemens Healthineers Atellica® CH platform. Assays studied included enzymes, proteins, lipids, electrolytes, and additional markers Reference intervals were established according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Of the 32 parameters, 26 required age partitioning and 18 required sex partitioning. Reference value distributions included consistent increases, decreases, and dynamic variation across the age continuum. Chloride, LDL cholesterol, glucose, lipase, sodium, and triglyceride demonstrated no age or sex-specific differences.
The current study expands the clinical utility of the CALIPER database to include 32 Siemens Atellica® chemistry assays. Reference value distributions for Siemens assays mirrored those observed on other comparable assays/systems with few exceptions (e.g. lipase, direct and total bilirubin). These finding support the robustness of previously derived reference intervals in the CALIPER cohort and other global cohorts.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2021.10.006</identifier><identifier>PMID: 34687749</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Age Factors ; Biomarkers - blood ; Blood Chemical Analysis ; CALIPER ; Chemistry ; Child ; Child, Preschool ; Databases, Factual ; Female ; Humans ; Male ; Pediatric ; Reference intervals ; Reference Values ; Sex Characteristics ; Sex Factors ; Siemens Atellica</subject><ispartof>Clinical biochemistry, 2022-01, Vol.99, p.69-77</ispartof><rights>2021 The Canadian Society of Clinical Chemists</rights><rights>Copyright © 2021 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-4816190f12e366ff98dcc9911359f995ed5c0d167dbabb069c96f62d3ec70d33</citedby><cites>FETCH-LOGICAL-c377t-4816190f12e366ff98dcc9911359f995ed5c0d167dbabb069c96f62d3ec70d33</cites><orcidid>0000-0002-5921-0454 ; 0000-0002-4716-4550</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2021.10.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34687749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bohn, Mary Kathryn</creatorcontrib><creatorcontrib>Horn, Paul</creatorcontrib><creatorcontrib>League, Donna</creatorcontrib><creatorcontrib>Steele, Paul</creatorcontrib><creatorcontrib>Hall, Alexandra</creatorcontrib><creatorcontrib>Adeli, Khosrow</creatorcontrib><title>Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>•Pediatric reference intervals were determined for 32 Siemens Atellica® CH assays.•Of 32 parameters, 26 required age partitioning and 18 required sex partitioning.•Assay reference distributions mirrored those on other systems with few exceptions.
Pediatric reference intervals are essential for test interpretation. With development of newer analytical systems, de novo reference interval establishment is of necessary importance. In the current study, pediatric reference intervals were determined for 32 analytes using Siemens Healthineers Atellica® CH assays in the CALIPER cohort of healthy children and adolescents.
Approximately 600 healthy children and adolescents were recruited with informed consent and collected serum samples were analyzed on the Siemens Healthineers Atellica® CH platform. Assays studied included enzymes, proteins, lipids, electrolytes, and additional markers Reference intervals were established according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Of the 32 parameters, 26 required age partitioning and 18 required sex partitioning. Reference value distributions included consistent increases, decreases, and dynamic variation across the age continuum. Chloride, LDL cholesterol, glucose, lipase, sodium, and triglyceride demonstrated no age or sex-specific differences.
The current study expands the clinical utility of the CALIPER database to include 32 Siemens Atellica® chemistry assays. Reference value distributions for Siemens assays mirrored those observed on other comparable assays/systems with few exceptions (e.g. lipase, direct and total bilirubin). These finding support the robustness of previously derived reference intervals in the CALIPER cohort and other global cohorts.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Biomarkers - blood</subject><subject>Blood Chemical Analysis</subject><subject>CALIPER</subject><subject>Chemistry</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Pediatric</subject><subject>Reference intervals</subject><subject>Reference Values</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Siemens Atellica</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u3CAUhVHVqJkkfYWK7rrxhJ8xNstq1DSRIiWL7BGG65gpxingSPMmeYo8RJ6sWDONuuwKwT2Hc-_9EPpKyZoSKi53a-Nd6NxkBhjXjDBa3teEiA9oRduGV0xy_hGtCCGykpSRU3SW0q5c2aYVn9Ap34i2aTZyhV7uwTqdozM4Qg8RggHsQob4rH3C_RQxZzhOc3YB8DHSGe3xqOMviAnPyYVHnAfAycEIIeEBtM9D0S9lncH7Ynh7xdtrrFPS-1QCjqI9NoPztsRiHSzWdvKQDIScLtBJXzqAz8fzHD1c_XjYXle3dz9vtt9vK8ObJleblgoqSU8ZcCH6XrbWGCkp5bXspazB1oZYKhrb6a4jQhopesEsB9MQy_k5-nb49ilOv2dIWY2uNOC9DjDNSbG6rbmggtRFKg9SE6eUyrbUU3RlC3tFiVq4qJ36h4tauCylwqV4vxxj5m4E--78C6IItgcBlFmfHUSVjFtgWBfBZGUn9x8xfwARg6jU</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Bohn, Mary Kathryn</creator><creator>Horn, Paul</creator><creator>League, Donna</creator><creator>Steele, Paul</creator><creator>Hall, Alexandra</creator><creator>Adeli, Khosrow</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5921-0454</orcidid><orcidid>https://orcid.org/0000-0002-4716-4550</orcidid></search><sort><creationdate>202201</creationdate><title>Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents</title><author>Bohn, Mary Kathryn ; Horn, Paul ; League, Donna ; Steele, Paul ; Hall, Alexandra ; Adeli, Khosrow</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-4816190f12e366ff98dcc9911359f995ed5c0d167dbabb069c96f62d3ec70d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Biomarkers - blood</topic><topic>Blood Chemical Analysis</topic><topic>CALIPER</topic><topic>Chemistry</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Pediatric</topic><topic>Reference intervals</topic><topic>Reference Values</topic><topic>Sex Characteristics</topic><topic>Sex Factors</topic><topic>Siemens Atellica</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bohn, Mary Kathryn</creatorcontrib><creatorcontrib>Horn, Paul</creatorcontrib><creatorcontrib>League, Donna</creatorcontrib><creatorcontrib>Steele, Paul</creatorcontrib><creatorcontrib>Hall, Alexandra</creatorcontrib><creatorcontrib>Adeli, Khosrow</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bohn, Mary Kathryn</au><au>Horn, Paul</au><au>League, Donna</au><au>Steele, Paul</au><au>Hall, Alexandra</au><au>Adeli, Khosrow</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2022-01</date><risdate>2022</risdate><volume>99</volume><spage>69</spage><epage>77</epage><pages>69-77</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>•Pediatric reference intervals were determined for 32 Siemens Atellica® CH assays.•Of 32 parameters, 26 required age partitioning and 18 required sex partitioning.•Assay reference distributions mirrored those on other systems with few exceptions.
Pediatric reference intervals are essential for test interpretation. With development of newer analytical systems, de novo reference interval establishment is of necessary importance. In the current study, pediatric reference intervals were determined for 32 analytes using Siemens Healthineers Atellica® CH assays in the CALIPER cohort of healthy children and adolescents.
Approximately 600 healthy children and adolescents were recruited with informed consent and collected serum samples were analyzed on the Siemens Healthineers Atellica® CH platform. Assays studied included enzymes, proteins, lipids, electrolytes, and additional markers Reference intervals were established according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Of the 32 parameters, 26 required age partitioning and 18 required sex partitioning. Reference value distributions included consistent increases, decreases, and dynamic variation across the age continuum. Chloride, LDL cholesterol, glucose, lipase, sodium, and triglyceride demonstrated no age or sex-specific differences.
The current study expands the clinical utility of the CALIPER database to include 32 Siemens Atellica® chemistry assays. Reference value distributions for Siemens assays mirrored those observed on other comparable assays/systems with few exceptions (e.g. lipase, direct and total bilirubin). These finding support the robustness of previously derived reference intervals in the CALIPER cohort and other global cohorts.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34687749</pmid><doi>10.1016/j.clinbiochem.2021.10.006</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5921-0454</orcidid><orcidid>https://orcid.org/0000-0002-4716-4550</orcidid></addata></record> |
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subjects | Adolescent Age Factors Biomarkers - blood Blood Chemical Analysis CALIPER Chemistry Child Child, Preschool Databases, Factual Female Humans Male Pediatric Reference intervals Reference Values Sex Characteristics Sex Factors Siemens Atellica |
title | Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents |
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