Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents

•Pediatric reference intervals were determined for 32 Siemens Atellica® CH assays.•Of 32 parameters, 26 required age partitioning and 18 required sex partitioning.•Assay reference distributions mirrored those on other systems with few exceptions. Pediatric reference intervals are essential for test...

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Veröffentlicht in:Clinical biochemistry 2022-01, Vol.99, p.69-77
Hauptverfasser: Bohn, Mary Kathryn, Horn, Paul, League, Donna, Steele, Paul, Hall, Alexandra, Adeli, Khosrow
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container_title Clinical biochemistry
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creator Bohn, Mary Kathryn
Horn, Paul
League, Donna
Steele, Paul
Hall, Alexandra
Adeli, Khosrow
description •Pediatric reference intervals were determined for 32 Siemens Atellica® CH assays.•Of 32 parameters, 26 required age partitioning and 18 required sex partitioning.•Assay reference distributions mirrored those on other systems with few exceptions. Pediatric reference intervals are essential for test interpretation. With development of newer analytical systems, de novo reference interval establishment is of necessary importance. In the current study, pediatric reference intervals were determined for 32 analytes using Siemens Healthineers Atellica® CH assays in the CALIPER cohort of healthy children and adolescents. Approximately 600 healthy children and adolescents were recruited with informed consent and collected serum samples were analyzed on the Siemens Healthineers Atellica® CH platform. Assays studied included enzymes, proteins, lipids, electrolytes, and additional markers Reference intervals were established according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Of the 32 parameters, 26 required age partitioning and 18 required sex partitioning. Reference value distributions included consistent increases, decreases, and dynamic variation across the age continuum. Chloride, LDL cholesterol, glucose, lipase, sodium, and triglyceride demonstrated no age or sex-specific differences. The current study expands the clinical utility of the CALIPER database to include 32 Siemens Atellica® chemistry assays. Reference value distributions for Siemens assays mirrored those observed on other comparable assays/systems with few exceptions (e.g. lipase, direct and total bilirubin). These finding support the robustness of previously derived reference intervals in the CALIPER cohort and other global cohorts.
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subjects Adolescent
Age Factors
Biomarkers - blood
Blood Chemical Analysis
CALIPER
Chemistry
Child
Child, Preschool
Databases, Factual
Female
Humans
Male
Pediatric
Reference intervals
Reference Values
Sex Characteristics
Sex Factors
Siemens Atellica
title Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents
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