An analysis of the biopharmaceutical behaviour of proton pump inhibitors with different physicochemical properties

At present, little information on the biopharmaceutical behaviour of proton pump inhibitors (PPIs) describing their absorption and biodistribution in vivo has been reported because the extreme instability of PPIs in the gastrointestinal environment makes it difficult to analyze such behaviour. In th...

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Veröffentlicht in:	Life sciences (1973) 2021-12, Vol.286, p.120042-120042, Article 120042
Hauptverfasser:	Jiang, Xindong, Shen, Tianxiang, Jin, Zhaolei, Li, Chunlong, Li, Qingpo, Qiu, Weigen, Cui, Yannan, Han, Zhihui, Hou, Xuemei, You, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	14C-radiolabelled 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology Absorption Absorption, Physicochemical - drug effects Absorption, Physicochemical - physiology Adsorption Animals Biodistribution Biological Products - pharmacokinetics Biological Products - pharmacology Biopharmaceuticals Biopharmaceutics Chemical Phenomena - drug effects China Colon Design optimization Duodenum Esomeprazole - pharmacology Female Gastrointestinal system Gastrointestinal tract High-performance liquid chromatography Ileum Ileum - metabolism Inhibitors Intestinal absorption Intestinal Absorption - drug effects Intestinal Absorption - physiology Intestine Jejunum Jejunum - metabolism Liquid chromatography Male Omeprazole Oral absorption behaviour Perfusion Physicochemical properties Proton pump inhibitors Proton Pump Inhibitors - metabolism Proton Pump Inhibitors - pharmacokinetics Proton Pump Inhibitors - pharmacology Protons Rabeprazole - pharmacology Radioactivity Radiolabelling Rats Rats, Sprague-Dawley Stability analysis Tandem Mass Spectrometry - methods Tissue Distribution - drug effects
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