Engineered Hyaluronic Acid-Based Smart Nanoconjugates for Enhanced Intracellular Drug Delivery

Bacterial polysaccharides can be easily modified to offer dual stimuli-responsive drug delivery systems with double targeting potential. In this research work, bacterial polysaccharides hyaluronic acid (HA) were functionalized with α-tocopherol polyethylene glycol succinate (TPGS) and cholic acid (C...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2023-06, Vol.112 (6), p.1603-1614
Hauptverfasser:	Arjama, Mukherjee, Mehnath, Sivaraj, Rajan, Mariappan, Jeyaraj, Murugaraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Disulfides Doxorubicin Drug Delivery Systems Drug Liberation Dual-targeted delivery Humans Hyaluronic acid Hyaluronic Acid - chemistry Hydrogen-Ion Concentration Nanoconjugates - chemistry Smart nanoconjugates α-tocopherol
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