Efficacy of Cathelicidin LL-37 in an MRSA Wound Infection Mouse Model

Background: LL-37 is the only human antimicrobial peptide that belongs to the cathelicidins. The aim of the study was to evaluate the efficacy of LL-37 in the management of MRSA-infected surgical wounds in mice. Methods: A wound on the back of adult male BALB/c mice was made and inoculated with Stap...

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Veröffentlicht in:	Antibiotics (Basel) 2021-10, Vol.10 (10), p.1210, Article 1210
Hauptverfasser:	Simonetti, Oriana, Cirioni, Oscar, Goteri, Gaia, Lucarini, Guendalina, Kamysz, Elzbieta, Kamysz, Wojciech, Orlando, Fiorenza, Rizzetto, Giulio, Molinelli, Elisa, Morroni, Gianluca, Ghiselli, Roberto, Provinciali, Mauro, Giacometti, Andrea, Offidani, Annamaria
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis animal models Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial peptides Bacteria Bacterial infections cathelicidin Cathelicidins Collagen Drug resistance Granulation Infectious Diseases Life Sciences & Biomedicine LL-37 Mode of action Pathogens Peptides Pharmacology & Pharmacy Science & Technology Skin Staphylococcus infections Teicoplanin Vascular endothelial growth factor VEGF wound Wound healing Wound infection
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