Next‐generation sequencing and genotype association studies reveal the association of HLA‐DRB302:02 with delayed hypersensitivity to penicillins

Background Nonimmediate (delayed)‐allergic reactions to penicillins are common and some of them can be life‐threatening. The genetic factors influencing these reactions are unknown/poorly known/poorly understood. We assessed the genetic predictors of a delayed penicillin allergy that cover the HLA l...

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Veröffentlicht in:	Allergy (Copenhagen) 2022-06, Vol.77 (6), p.1827-1834
Hauptverfasser:	Romano, Antonino, Oussalah, Abderrahim, Chery, Celine, Guéant‐Rodriguez, Rosa‐Maria, Gaeta, Francesco, Cornejo‐Garcia, Jose‐Antonio, Rouyer, Pierre, Josse, Thomas, Mayorga, Cristobalina, Torres, Maria‐Jose, Guéant, Jean‐Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles amoxicillin Antibiotics beta‐lactams drug allergy Drug Hypersensitivity - epidemiology Gene frequency Genetic diversity Genetic factors genome‐wide association Genotype Genotypes Genotyping Haplotypes High-Throughput Nucleotide Sequencing Histocompatibility antigen HLA HLA-DRB3 Chains - genetics HLA‐DRB3 Humans Hypersensitivity (delayed) Hypersensitivity (immediate) Hypersensitivity, Delayed - chemically induced Hypersensitivity, Delayed - genetics Hypersensitivity, Immediate - complications Major histocompatibility complex nonimmediate reactions Penicillin penicillins Penicillins - adverse effects
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