Polyphenols as anticancer agents: Toxicological concern to healthy cells

Polyphenols are a group of diverse chemical compounds present in a wide range of plants. Various biological properties such as antiallergic, antiviral, antibacterial, anticarcinogenic, antiinflammatory, antithrombotic, vasodilatory, and hepatoprotective effect of different polyphenols have been repo...

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Veröffentlicht in:Phytotherapy research 2021-11, Vol.35 (11), p.6063-6079
Hauptverfasser: Islam, Badar ul, Suhail, Mohd, Khan, Mohammed Kaleem, Zughaibi, Torki A., Alserihi, Raed F, Zaidi, Syed Kashif, Tabrez, Shams
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container_end_page 6079
container_issue 11
container_start_page 6063
container_title Phytotherapy research
container_volume 35
creator Islam, Badar ul
Suhail, Mohd
Khan, Mohammed Kaleem
Zughaibi, Torki A.
Alserihi, Raed F
Zaidi, Syed Kashif
Tabrez, Shams
description Polyphenols are a group of diverse chemical compounds present in a wide range of plants. Various biological properties such as antiallergic, antiviral, antibacterial, anticarcinogenic, antiinflammatory, antithrombotic, vasodilatory, and hepatoprotective effect of different polyphenols have been reported in the scientific literature. The major classes of polyphenols are flavonoids, stilbenoids, lignans, and polyphenolic acids. Flavonoids are a large class of food constituents comprising flavones, isoflavanones, flavanones, flavonols, catechins, and anthocyanins sub‐classes. Even with seemingly broad biological activities, their use is minimal clinically. Among the other concurrent problems such as limited bioavailability, rapid metabolism, untargeted delivery, the toxicity associated with these polyphenols has been a topic of concern lately. These polyphenols have been reported to result in different forms of toxicity that include organ toxicity, genotoxicity, mutagenicity, cytotoxicity, etc. In the present article, we have tried to unravel the toxicological aspect of these polyphenols to healthy cells. Further high‐quality studies are needed to establish the clinical efficacy and toxicology concern leading to further exploration of these polyphenols.
doi_str_mv 10.1002/ptr.7216
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source Wiley Journals
subjects Anthocyanins
Anticancer properties
Antitumor agents
Antiviral activity
Apoptosis
Bioavailability
Biological properties
Catechin
Chemical compounds
clastogenic activity
Cytotoxicity
Flavones
Flavonoids
Flavonols
Genotoxicity
Lignans
Metabolism
Mutagenicity
Polyphenols
Toxicity
Toxicology
title Polyphenols as anticancer agents: Toxicological concern to healthy cells
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