Delivery of Anti-IFNAR1 shRNA to Hepatic Cells Decreases IFNAR1 Gene Expression and Improves Adenoviral Transduction and Transgene Expression

Chronic liver injury leads to advanced fibrosis, cirrhosis, and hepatocellular carcinoma. Genetical cell treatment related to the use of adenovirus (Ads) has proven to be beneficial and efficient in the recovery of hepatic diseases. Nevertheless, they are highly immunogenic and trigger an immune res...

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Veröffentlicht in:	Molecular biotechnology 2022-04, Vol.64 (4), p.413-423
Hauptverfasser:	Guerrero-Rodríguez, J., Cárdenas-Vargas, A., Gutierrez-Silerio, G., Sobrevilla-Navarro, A., Bastidas-Ramírez, B., Hernández-Ortega, L., Gurrola-Díaz, C., Gasca-Lozano, L., Armendáriz-Borunda, J., Salazar-Montes, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Biochemistry Biological Techniques Biotechnology Cell activation Cell Biology Chemistry Chemistry and Materials Science Cirrhosis eIF-2 kinase Expression vectors Fibrosis Fluorescence Gene expression Green fluorescent protein Hepatocellular carcinoma Human Genetics Immune response Immune system Immunogenicity Interferon Kinases Liver cancer Liver cirrhosis Liver diseases Macrophages Original Paper Plasmids Protein kinase Protein Science Proteins Stat1 protein Transduction Transfection Transgenes Tumor necrosis factor-α α-Interferon
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