uORF‐mediated riboregulation controls transcription of whiB7/wblC antibiotic resistance gene

WhiB7/WblC is a transcriptional factor of actinomycetes conferring intrinsic resistance to multiple translation‐inhibitory antibiotics. It positively autoregulates its own transcription in response to the same antibiotics. The presence of a uORF and a potential Rho‐independent transcription terminat...

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Veröffentlicht in:	Molecular microbiology 2022-01, Vol.117 (1), p.179-192
Hauptverfasser:	Lee, Ju‐Hyung, Lee, Eun‐Jin, Roe, Jung‐Hye
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Actinobacteria - genetics Actinobacteria - physiology Actinomycetes Amino acid starvation Amino acids Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics antiterminator Attenuation Attenuators Bacterial Proteins - genetics Bacterial Proteins - metabolism Drug resistance Drug Resistance, Bacterial - genetics Gene Expression Regulation, Bacterial Mycobacterium Mycobacterium - genetics Mycobacterium - physiology Ribosomes - metabolism Streptomyces Streptomyces coelicolor - genetics Streptomyces coelicolor - physiology transcription attenuation Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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