Application of liquid chromatography coupled to data-independent acquisition mass spectrometry for the metabolic profiling of N-ethyl heptedrone

[Display omitted] •The metabolic profile of N-ethyl heptedrone was characterized by LC-HRMS.•N-ethyl heptedrone is extensively metabolized to 13 phase-1 metabolites.•The markers of exposure are formed by N-dealkylation, reduction and hydroxylation.•Phase 2 (glucuronidation) involves mostly the hydro...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2021-11, Vol.1185, p.122989-122989, Article 122989
Hauptverfasser:	Mazzarino, Monica, Camuto, Cristian, Comunità, Fabio, de la Torre, Xavier, Stacchini, Carlotta, Botrè, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotransformation Chromatography, Liquid - methods Cytochrome P-450 CYP3A - metabolism Designer Drugs - analysis Designer Drugs - metabolism Female Humans Hydroxylation In vitro metabolism Ketones - chemistry Ketones - urine Liquid chromatography – high resolution mass spectrometry Male Mass Spectrometry - methods Metabolome Metabolomics Microsomes, Liver - chemistry Microsomes, Liver - metabolism Molecular Structure N-ethyl heptedrone Novel Psychoactive Substances Psychotropic Drugs - chemistry Psychotropic Drugs - urine Quinazolines - chemistry Quinazolines - metabolism SWATH
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