Leveraging immune memory against measles virus as an antitumor strategy in a preclinical model of aggressive squamous cell carcinoma

Viral antigens are among the strongest elicitors of immune responses. A significant proportion of the human population already carries pre-existing immunity against several childhood viruses, which could potentially be leveraged to fight cancer. We sought to provide proof of concept in mouse models...

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Veröffentlicht in:	Journal for immunotherapy of cancer 2021-10, Vol.9 (10), p.e002170, Article 002170
Hauptverfasser:	Leb-Reichl, Victoria M, Kienzl, Melanie, Kaufmann, Anna, Stoecklinger, Angelika, Tockner, Birgit, Kitzmueller, Sophie, Zaborsky, Nadja, Steiner, Markus, Brachtl, Gabriele, Trattner, Lisa, Kreideweiss, Patrick, Reinsch, Christian, Panzner, Steffen, Greil, Richard, Strunk, Dirk, Bauer, Johann W, Gratz, Iris K, Guttmann-Gruber, Christina, Piñón Hofbauer, Josefina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Cancer Cancer vaccines Carcinoma, Squamous Cell - immunology CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - immunology Cell growth cellular Cytokines Cytotoxicity Dendritic cells Disease Models, Animal Experiments Flow cytometry Humans immunity immunogenicity Immunologic Memory - immunology Immunology Immunotherapy investigational Life Sciences & Biomedicine Lymphocytes Measles Measles virus - immunology Mice Mutation Oncology Oncolytic and Local Immunotherapy Peptides Proteins Science & Technology Skin cancer skin neoplasms Squamous cell carcinoma therapies Tumors vaccine Vaccines Viruses
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