Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium

Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by loss of function TP53 and RB1 mutations in addition to mutations in other oncogenes including MYC . Overexpression of MYC together with Trp53 and Rb1 loss in pulmonary neuroendocrine cells of the mouse lung drives...

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Veröffentlicht in:	Oncogene 2022-01, Vol.41 (1), p.138-145
Hauptverfasser:	Chen, Jasmine, Guanizo, Aleks, Luong, Quinton, Jayasekara, W. Samantha N., Jayasinghe, Dhilshan, Inampudi, Chaitanya, Szczepny, Anette, Garama, Daniel J., Russell, Prudence A., Ganju, Vinod, Cain, Jason E., Watkins, D. Neil, Gough, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	14 38 38/91 631/67 631/67/1612/2143 64/60 Adenoma Alveoli Animals Apoptosis Brief Communication Cell Biology Cell lineage Epithelium Human Genetics Humans Internal Medicine Invasiveness Latency Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medicine Medicine & Public Health Metastases Mice Mutation Myc protein Neuroendocrine tumors Oncogenes - physiology Oncology p53 Protein Phenotypes Respiratory tract Retinoblastoma Retinoblastoma Protein - metabolism Small cell lung carcinoma Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - pathology Transcription Tumor Suppressor Protein p53 - metabolism
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