Amalgamation of Solid Dispersion and Melt Adsorption Technique: Improved In Vitro and In Vivo Performance of Ticagrelor Tablets

Ticagrelor (TG) suffers from low peroral bioabsorption (36%) due to P-gp efflux and poor solubility (10 µg/mL). TG solid dispersion adsorbates (TG-SDAs) were formulated using an amalgamation of solid dispersion and melt adsorption techniques which were simple, economic, scalable, and solvent-free. F...

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Veröffentlicht in:	AAPS PharmSciTech 2021-10, Vol.22 (8), p.257-257, Article 257
Hauptverfasser:	Yadav, Mukesh, Sarolia, Jayant, Vyas, Bhavin, Lalan, Manisha, Mangrulkar, Shubhada, Shah, Pranav
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Biochemistry Biological Availability Biomedical and Life Sciences Biomedicine Biotechnology Caco-2 Cells Calorimetry, Differential Scanning Chemistry, Pharmaceutical Excipients Humans Pharmacology/Toxicology Pharmacy Rats Research Article Solubility Tablets Ticagrelor
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