Transcriptional inhibition of steroidogenic factor 1 in vivo in Oreochromis niloticus increased weight and suppressed gonad development

•sf1 gene-silenced tilapia was constructed through antisense RNA.•sf1 gene transcription and protein levels are significantly suppressed.•The weight of sf1 gene-silencing tilapia increased significantly.•sf1 gene-silencing tilapia show metabolic disorders and gonad abnormality. Steroidogenic factor...

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Veröffentlicht in:	Gene 2022-01, Vol.809, p.146023-146023, Article 146023
Hauptverfasser:	Cao, Zhe-Ming, Qiang, Jun, Zhu, Jun-Hao, Li, Hong-Xia, Tao, Yi-Fan, He, Jie, Xu, Pao, Dong, Zai-Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense RNA Aquaculture Body Weight - genetics Cichlids - genetics Cichlids - growth & development Down-Regulation Female Fish Proteins - genetics Fish Proteins - metabolism Gene Expression Regulation Male Oreochromis niloticus Ovary - growth & development RNA, Antisense Signal pathway Steroidogenic factor 1 Steroidogenic Factor 1 - genetics Steroidogenic Factor 1 - metabolism Testis - growth & development Transcription suppression Transfection
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