Ultra-deep sequencing mutation analysis of the BCR/ABL1 kinase domain in newly diagnosed chronic myeloid leukemia patients

•Ultra-deep sequencing is a sensitive method for genetic-based treatment decisions.•Specific mutations could have a prognostic application in predicting response.•Based on mutational analyses, nilotinib is a promising option for Korean patients. Ultra-deep sequencing detects low-frequency genetic mu...

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Veröffentlicht in:	Leukemia research 2021-12, Vol.111, p.106728-106728, Article 106728
Hauptverfasser:	Park, Hyunkyung, Kim, Inho, Kim, Hyeong-Joon, Shin, Dong-Yeop, Lee, Sung-Yeoun, Kwon, Oh-Hyung, Kim, Dae-Young, Lee, Kyoo-Hyung, Ahn, Jae-Sook, Park, Jinny, Sohn, Sang-Kyun, Lee, Jeong-Ok, Cheong, June-Won, Kim, Kyoung Ha, Kim, Hoon-Gu, Kim, Hawk, Lee, Yoo Jin, Nam, Seung-Hyun, Do, Young Rok, Park, Sang-Gon, Park, Seong Kyu, Bae, Sung Hwa, Song, Hun Ho, Oh, Doyeun, Jung, Chul Won, Park, Seonyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use BCR-ABL1 tyrosine kinase Biomarkers, Tumor - genetics Chronic myeloid leukemia Dasatinib - administration & dosage Drug Resistance, Neoplasm - genetics Female Follow-Up Studies Fusion Proteins, bcr-abl - genetics High-Throughput Nucleotide Sequencing Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Male Middle Aged Molecular response Mutation Mutations Prognosis Prospective Studies Pyrimidines - administration & dosage Survival Rate Ultra-deep sequencing
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