Inhibition of Mycobacterium tuberculosis InhA by 3‐nitropropanoic acid

3‐Nitropropanoic acid (3NP), a bioactive fungal natural product, was previously demonstrated to inhibit growth of Mycobacterium tuberculosis. Here we demonstrate that 3NP inhibits the 2‐trans‐enoyl‐acyl carrier protein reductase (InhA) from Mycobacterium tuberculosis with an IC50 value of 71 μM, and...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2022-03, Vol.90 (3), p.898-904
Hauptverfasser:	Songsiriritthigul, Chomphunuch, Hanwarinroj, Chayanin, Pakamwong, Bongkochawan, Srimanote, Potjanee, Suttipanta, Nitima, Sureram, Sanya, Suttisintong, Khomson, Kamsri, Pharit, Punkvang, Auradee, Spencer, James, Kittakoop, Prasat, Pungpo, Pornpan
Format:	Artikel
Sprache:	eng
Schlagworte:	3‐nitropropanoic acid Acyl carrier protein antituberculosis Bacterial Proteins - antagonists & inhibitors Binding Sites bioactive compound Crystal structure Diphenyl ether Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Hydrophobicity InhA Models, Molecular Mycobacterium tuberculosis Mycobacterium tuberculosis - chemistry NAD NAD - chemistry Natural products Nitro Compounds - chemistry Oxidoreductases - antagonists & inhibitors Phenyl Ethers - chemistry Propionates - chemistry Protein Binding Protein Conformation Proteins Reductases Structure-Activity Relationship Substrate inhibition Triclosan Tuberculosis
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