An in vitro system to silence mitochondrial gene expression

The human mitochondrial genome encodes thirteen core subunits of the oxidative phosphorylation system, and defects in mitochondrial gene expression lead to severe neuromuscular disorders. However, the mechanisms of mitochondrial gene expression remain poorly understood due to a lack of experimental...

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Veröffentlicht in:	Cell 2021-11, Vol.184 (23), p.5824-5837.e15
Hauptverfasser:	Cruz-Zaragoza, Luis Daniel, Dennerlein, Sven, Linden, Andreas, Yousefi, Roya, Lavdovskaia, Elena, Aich, Abhishek, Falk, Rebecca R., Gomkale, Ridhima, Schöndorf, Thomas, Bohnsack, Markus T., Richter-Dennerlein, Ricarda, Urlaub, Henning, Rehling, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	antisense Electron Transport Electron Transport Complex IV - genetics Gene Expression Regulation Gene Silencing Genes, Mitochondrial HEK293 Cells Humans IGF2BP1 mitochondria Mitochondrial Proteins - metabolism mitochondrial ribosome morpholino Oligonucleotides - chemistry Oxidative Phosphorylation Protein Biosynthesis Protein Subunits - metabolism Ribosomes - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Mitochondrial - metabolism RNA-Binding Proteins - metabolism Saccharomyces cerevisiae - metabolism translation
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