Flexible linker modulates the binding affinity of the TP901‐1 CI phage repressor to DNA

Temperate bacteriophages can switch between two life cycles following infection of a host bacterium: the lytic or lysogenic life cycle. The choice between these is controlled by a bistable genetic switch. We investigated the genetic switch of the lactococcal temperate bacteriophage, TP901‐1, which i...

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Veröffentlicht in:	The FEBS journal 2022-02, Vol.289 (4), p.1135-1148
Hauptverfasser:	Varming, Anders Kokkenborg, Rasmussen, Kim Krighaar, Zong, Zhiyou, Thulstrup, Peter Waaben, Kilstrup, Mogens, Lo Leggio, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity bacteriophage Bacteriophages - genetics Bacteriophages - metabolism Binding Binding Sites Circular dichroism Deoxyribonucleic acid Dichroism DNA DNA - chemistry DNA - metabolism Domains Electrophoresis Electrophoretic mobility flexible linker Fluorimetry Gene silencing genetic switch Isoelectric focusing Life cycles lysogeny Models, Molecular Molecular dynamics Oligomerization Phages Regulatory proteins repressor Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Scattering, Small Angle Spectroscopy X-Rays
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