Impact of magnesium on bone health in older adults: A systematic review and meta-analysis
Magnesium plays a key role in bone health and may, therefore, represent an interesting nutrient for the prevention of bone loss and osteoporosis. The aim of this systematic review and meta-analysis was to investigate the impact of magnesium intake from any source on bone mineral density (BMD), bone...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2022-01, Vol.154, p.116233-116233, Article 116233 |
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| container_title | Bone (New York, N.Y.) |
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| creator | Groenendijk, Inge van Delft, Marieke Versloot, Pieter van Loon, Luc J.C. de Groot, Lisette C.P.G.M. |
| description | Magnesium plays a key role in bone health and may, therefore, represent an interesting nutrient for the prevention of bone loss and osteoporosis. The aim of this systematic review and meta-analysis was to investigate the impact of magnesium intake from any source on bone mineral density (BMD), bone mineral content (BMC), bone turnover markers, and fracture risk in older adults.
A systematic search was conducted using Embase, Medline Ovid and Cochrane Central from database inception to October 2020. All studies that related magnesium intake with bone health outcomes among adults aged ≥60 years were included. Two investigators independently conducted abstract and full-text screenings, data extractions, and risk of bias assessments. Authors were contacted for missing data.
Once 787 records were screened, six cohort studies, one case-control study and five cross-sectional studies were included. Qualitative evaluation demonstrated a positive trend between higher magnesium intake and higher hip and femoral neck BMD. Meta-analysis of four studies showed a significant positive association between magnesium intake and hip BMD (pooled beta: 0.03, 95% CI: 0.01–0.06, p |
| doi_str_mv | 10.1016/j.bone.2021.116233 |
| format | Article |
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A systematic search was conducted using Embase, Medline Ovid and Cochrane Central from database inception to October 2020. All studies that related magnesium intake with bone health outcomes among adults aged ≥60 years were included. Two investigators independently conducted abstract and full-text screenings, data extractions, and risk of bias assessments. Authors were contacted for missing data.
Once 787 records were screened, six cohort studies, one case-control study and five cross-sectional studies were included. Qualitative evaluation demonstrated a positive trend between higher magnesium intake and higher hip and femoral neck BMD. Meta-analysis of four studies showed a significant positive association between magnesium intake and hip BMD (pooled beta: 0.03, 95% CI: 0.01–0.06, p < 0.05).
This systematic review indicates that a higher magnesium intake may support an increase in hip and femoral neck BMD. Due to limited research no associations with BMD at other sites or fractures were found. There is a need for properly designed cohort studies to determine the association between magnesium intake and bone health in older adults. Next, large and long-term randomized controlled trials in older adults are needed to determine whether an increase in magnesium (supplementation) intake can improve bone health. The combination of several bone nutrients (calcium, vitamin D, protein, magnesium and potentially more) may be needed for the most optimal effect on bone health and to delay or prevent the development of osteoporosis.
•Higher magnesium intake is associated with higher hip and femoral neck bone mineral density.•Not enough evidence for relationship between magnesium and other bone outcomes.•Focus for future research should be on properly designed cohort studies.•Impact of nutrition on bone health can be attributed to a variety of nutrients.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2021.116233</identifier><identifier>PMID: 34666201</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Bone ; Bone Density ; Bone mineral density ; Case-Control Studies ; Cross-Sectional Studies ; Fracture ; Humans ; Magnesium ; Middle Aged ; Older adults ; Osteoporosis - prevention & control</subject><ispartof>Bone (New York, N.Y.), 2022-01, Vol.154, p.116233-116233, Article 116233</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-b644e7523464f458ff780d6b861857527da146f35e3d4b75239795cc8a557d933</citedby><cites>FETCH-LOGICAL-c400t-b644e7523464f458ff780d6b861857527da146f35e3d4b75239795cc8a557d933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S8756328221003999$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34666201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Groenendijk, Inge</creatorcontrib><creatorcontrib>van Delft, Marieke</creatorcontrib><creatorcontrib>Versloot, Pieter</creatorcontrib><creatorcontrib>van Loon, Luc J.C.</creatorcontrib><creatorcontrib>de Groot, Lisette C.P.G.M.</creatorcontrib><title>Impact of magnesium on bone health in older adults: A systematic review and meta-analysis</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Magnesium plays a key role in bone health and may, therefore, represent an interesting nutrient for the prevention of bone loss and osteoporosis. The aim of this systematic review and meta-analysis was to investigate the impact of magnesium intake from any source on bone mineral density (BMD), bone mineral content (BMC), bone turnover markers, and fracture risk in older adults.
A systematic search was conducted using Embase, Medline Ovid and Cochrane Central from database inception to October 2020. All studies that related magnesium intake with bone health outcomes among adults aged ≥60 years were included. Two investigators independently conducted abstract and full-text screenings, data extractions, and risk of bias assessments. Authors were contacted for missing data.
Once 787 records were screened, six cohort studies, one case-control study and five cross-sectional studies were included. Qualitative evaluation demonstrated a positive trend between higher magnesium intake and higher hip and femoral neck BMD. Meta-analysis of four studies showed a significant positive association between magnesium intake and hip BMD (pooled beta: 0.03, 95% CI: 0.01–0.06, p < 0.05).
This systematic review indicates that a higher magnesium intake may support an increase in hip and femoral neck BMD. Due to limited research no associations with BMD at other sites or fractures were found. There is a need for properly designed cohort studies to determine the association between magnesium intake and bone health in older adults. Next, large and long-term randomized controlled trials in older adults are needed to determine whether an increase in magnesium (supplementation) intake can improve bone health. The combination of several bone nutrients (calcium, vitamin D, protein, magnesium and potentially more) may be needed for the most optimal effect on bone health and to delay or prevent the development of osteoporosis.
•Higher magnesium intake is associated with higher hip and femoral neck bone mineral density.•Not enough evidence for relationship between magnesium and other bone outcomes.•Focus for future research should be on properly designed cohort studies.•Impact of nutrition on bone health can be attributed to a variety of nutrients.</description><subject>Aged</subject><subject>Bone</subject><subject>Bone Density</subject><subject>Bone mineral density</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Fracture</subject><subject>Humans</subject><subject>Magnesium</subject><subject>Middle Aged</subject><subject>Older adults</subject><subject>Osteoporosis - prevention & control</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLJDEURoM4aPv4Ay4kSzfV5p20uBGZGQXBzcxiViGV3NI09WiTlNL_fqro1qWrC5fzfdx7ELqgZEkJVdfrZT30sGSE0SWlinF-gBbUaF4xrfghWhgtVcWZYcfoJOc1IYSvND1Cx1wopRihC_Tvsds4X_DQ4M699JDj2OGhx3MzfgXXllccezy0ARJ2YWxLvsF3OG9zgc6V6HGC9wgf2PUBd1Bc5XrXbnPMZ-hH49oM5_t5iv7--vnn_qF6ev79eH_3VHlBSKlqJQRoyaaTRCOkaRptSFC1UdTIaa-Do0I1XAIPop7BlV5J742TUocV56foate7ScPbCLnYLmYPbet6GMZsmTSCUKmEmVC2Q30ack7Q2E2KnUtbS4mdldq1nR-3s1K7UzqFLvf9Y91B-Ip8OpyA2x0A05eTi2Szj9B7CDGBLzYM8bv-_zbuhfU</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Groenendijk, Inge</creator><creator>van Delft, Marieke</creator><creator>Versloot, Pieter</creator><creator>van Loon, Luc J.C.</creator><creator>de Groot, Lisette C.P.G.M.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202201</creationdate><title>Impact of magnesium on bone health in older adults: A systematic review and meta-analysis</title><author>Groenendijk, Inge ; van Delft, Marieke ; Versloot, Pieter ; van Loon, Luc J.C. ; de Groot, Lisette C.P.G.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-b644e7523464f458ff780d6b861857527da146f35e3d4b75239795cc8a557d933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Bone</topic><topic>Bone Density</topic><topic>Bone mineral density</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Fracture</topic><topic>Humans</topic><topic>Magnesium</topic><topic>Middle Aged</topic><topic>Older adults</topic><topic>Osteoporosis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Groenendijk, Inge</creatorcontrib><creatorcontrib>van Delft, Marieke</creatorcontrib><creatorcontrib>Versloot, Pieter</creatorcontrib><creatorcontrib>van Loon, Luc J.C.</creatorcontrib><creatorcontrib>de Groot, Lisette C.P.G.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Groenendijk, Inge</au><au>van Delft, Marieke</au><au>Versloot, Pieter</au><au>van Loon, Luc J.C.</au><au>de Groot, Lisette C.P.G.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of magnesium on bone health in older adults: A systematic review and meta-analysis</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2022-01</date><risdate>2022</risdate><volume>154</volume><spage>116233</spage><epage>116233</epage><pages>116233-116233</pages><artnum>116233</artnum><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Magnesium plays a key role in bone health and may, therefore, represent an interesting nutrient for the prevention of bone loss and osteoporosis. The aim of this systematic review and meta-analysis was to investigate the impact of magnesium intake from any source on bone mineral density (BMD), bone mineral content (BMC), bone turnover markers, and fracture risk in older adults.
A systematic search was conducted using Embase, Medline Ovid and Cochrane Central from database inception to October 2020. All studies that related magnesium intake with bone health outcomes among adults aged ≥60 years were included. Two investigators independently conducted abstract and full-text screenings, data extractions, and risk of bias assessments. Authors were contacted for missing data.
Once 787 records were screened, six cohort studies, one case-control study and five cross-sectional studies were included. Qualitative evaluation demonstrated a positive trend between higher magnesium intake and higher hip and femoral neck BMD. Meta-analysis of four studies showed a significant positive association between magnesium intake and hip BMD (pooled beta: 0.03, 95% CI: 0.01–0.06, p < 0.05).
This systematic review indicates that a higher magnesium intake may support an increase in hip and femoral neck BMD. Due to limited research no associations with BMD at other sites or fractures were found. There is a need for properly designed cohort studies to determine the association between magnesium intake and bone health in older adults. Next, large and long-term randomized controlled trials in older adults are needed to determine whether an increase in magnesium (supplementation) intake can improve bone health. The combination of several bone nutrients (calcium, vitamin D, protein, magnesium and potentially more) may be needed for the most optimal effect on bone health and to delay or prevent the development of osteoporosis.
•Higher magnesium intake is associated with higher hip and femoral neck bone mineral density.•Not enough evidence for relationship between magnesium and other bone outcomes.•Focus for future research should be on properly designed cohort studies.•Impact of nutrition on bone health can be attributed to a variety of nutrients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34666201</pmid><doi>10.1016/j.bone.2021.116233</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Bone Bone Density Bone mineral density Case-Control Studies Cross-Sectional Studies Fracture Humans Magnesium Middle Aged Older adults Osteoporosis - prevention & control |
| title | Impact of magnesium on bone health in older adults: A systematic review and meta-analysis |
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