Engineering of cis-Element in Saccharomyces cerevisiae for Efficient Accumulation of Value-Added Compound Squalene via Downregulation of the Downstream Metabolic Flux

Transcriptional downregulation is widely used for metabolic flux control. Here, marO, a cis-element of Escherichia coli mar operator, was explored to engineer promoters of Saccharomyces cerevisiae for downregulation. First, the ADH1 promoter (P ADH1 ) and its enhanced variant P UADH1 were engineered...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2021-10, Vol.69 (42), p.12474-12484
Hauptverfasser:	Zhou, Chenyao, Li, Mingjie, Lu, Surui, Cheng, Yanfei, Guo, Xuena, He, Xiaoxian, Wang, Zhaoyue, He, Xiu-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology and Biological Transformations
Online-Zugang:	Volltext
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