Comprehensive phenotyping of human peripheral blood B lymphocytes in healthy conditions

The B cell compartment provides innate and adaptive immune defenses against pathogens. Different B cell subsets, reflecting the maturation stages of B cells, have noninterchangeable functions and roles in innate and adaptive immune responses. In this review, we provide an overview of the B cell subs...

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Veröffentlicht in:Cytometry. Part A 2022-02, Vol.101 (2), p.131-139
Hauptverfasser: Carsetti, Rita, Terreri, Sara, Conti, Maria Giulia, Fernandez Salinas, Ane, Corrente, Francesco, Capponi, Claudia, Albano, Christian, Piano Mortari, Eva
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container_end_page 139
container_issue 2
container_start_page 131
container_title Cytometry. Part A
container_volume 101
creator Carsetti, Rita
Terreri, Sara
Conti, Maria Giulia
Fernandez Salinas, Ane
Corrente, Francesco
Capponi, Claudia
Albano, Christian
Piano Mortari, Eva
description The B cell compartment provides innate and adaptive immune defenses against pathogens. Different B cell subsets, reflecting the maturation stages of B cells, have noninterchangeable functions and roles in innate and adaptive immune responses. In this review, we provide an overview of the B cell subsets present in peripheral blood of healthy individuals. A specific gating strategy is also described to clearly and univocally identify B cell subsets based on the their phenotypic traits by flow cytometric analysis.
doi_str_mv 10.1002/cyto.a.24507
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source Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Adaptive immunity
B cell subsets
B-Lymphocytes
Blood
Flow Cytometry
Gating
human B cells
Humans
Lymphocytes
Lymphocytes B
Peripheral blood
Phenotype
Phenotyping
title Comprehensive phenotyping of human peripheral blood B lymphocytes in healthy conditions
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