Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration
► In this work, we developed biocompatible alginate/nano bioglass composite scaffolds for periodontal tissue regeneration. ► This nanocomposite scaffold is biocompatible with human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells. ► The hPDLF cells also behaved as osteoblasts s...
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| Veröffentlicht in: | Carbohydrate polymers 2012-01, Vol.87 (1), p.274-283 |
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| creator | Srinivasan, Sowmya Jayasree, R. Chennazhi, K.P. Nair, S.V. Jayakumar, R. |
| description | ► In this work, we developed biocompatible alginate/nano bioglass composite scaffolds for periodontal tissue regeneration. ► This nanocomposite scaffold is biocompatible with human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells. ► The hPDLF cells also behaved as osteoblasts showing enhanced alkaline phosphatase activity.
Periodontal regeneration is of utmost importance in the field of dentistry which essentially reconstitutes and replaces the lost tooth supporting structures. For this purpose, nano bioactive glass ceramic particle (nBGC) incorporated alginate composite scaffold was fabricated and characterized using SEM, EDAX, AFM, FTIR, XRD and other methods. The swelling ability, in vitro degradation, biomineralization and cytocompatibility of the scaffold were also evaluated. The results indicated reduced swelling and degradation and enhanced biomineralization and protein adsorption. In addition, the human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells were viable, adhered and proliferated well on the alginate/bioglass composite scaffolds in comparison to the control alginate scaffolds. The presence of nBGC enhanced the alkaline phosphatase (ALP) activity of the hPDLF cells cultured on the composite scaffolds. Thus results suggest that these biocompatible composite scaffolds can be useful for periodontal tissue regeneration. |
| doi_str_mv | 10.1016/j.carbpol.2011.07.058 |
| format | Article |
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Periodontal regeneration is of utmost importance in the field of dentistry which essentially reconstitutes and replaces the lost tooth supporting structures. For this purpose, nano bioactive glass ceramic particle (nBGC) incorporated alginate composite scaffold was fabricated and characterized using SEM, EDAX, AFM, FTIR, XRD and other methods. The swelling ability, in vitro degradation, biomineralization and cytocompatibility of the scaffold were also evaluated. The results indicated reduced swelling and degradation and enhanced biomineralization and protein adsorption. In addition, the human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells were viable, adhered and proliferated well on the alginate/bioglass composite scaffolds in comparison to the control alginate scaffolds. The presence of nBGC enhanced the alkaline phosphatase (ALP) activity of the hPDLF cells cultured on the composite scaffolds. Thus results suggest that these biocompatible composite scaffolds can be useful for periodontal tissue regeneration.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2011.07.058</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>adsorption ; Alginate ; Alkaline phosphatase ; Applied sciences ; bioactive properties ; Bioglass ; Biological and medical sciences ; biomineralization ; cell viability ; ceramics ; Composites ; cultured cells ; dentistry ; energy-dispersive X-ray analysis ; Exact sciences and technology ; fibroblasts ; Forms of application and semi-finished materials ; Fourier transform infrared spectroscopy ; glass ; humans ; ligaments ; Medical sciences ; Nanocomposite ; osteosarcoma ; Periodontal regeneration ; Polymer industry, paints, wood ; scanning electron microscopy ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology of polymers ; Technology. Biomaterials. Equipments ; Tissue engineering ; tissue repair ; X-ray diffraction</subject><ispartof>Carbohydrate polymers, 2012-01, Vol.87 (1), p.274-283</ispartof><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-1b278dbd703ac0f5081a0447b69398e9f5f62a6cfee780d50a7d7372c7d7f7c43</citedby><cites>FETCH-LOGICAL-c396t-1b278dbd703ac0f5081a0447b69398e9f5f62a6cfee780d50a7d7372c7d7f7c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2011.07.058$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24698506$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Srinivasan, Sowmya</creatorcontrib><creatorcontrib>Jayasree, R.</creatorcontrib><creatorcontrib>Chennazhi, K.P.</creatorcontrib><creatorcontrib>Nair, S.V.</creatorcontrib><creatorcontrib>Jayakumar, R.</creatorcontrib><title>Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration</title><title>Carbohydrate polymers</title><description>► In this work, we developed biocompatible alginate/nano bioglass composite scaffolds for periodontal tissue regeneration. ► This nanocomposite scaffold is biocompatible with human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells. ► The hPDLF cells also behaved as osteoblasts showing enhanced alkaline phosphatase activity.
Periodontal regeneration is of utmost importance in the field of dentistry which essentially reconstitutes and replaces the lost tooth supporting structures. For this purpose, nano bioactive glass ceramic particle (nBGC) incorporated alginate composite scaffold was fabricated and characterized using SEM, EDAX, AFM, FTIR, XRD and other methods. The swelling ability, in vitro degradation, biomineralization and cytocompatibility of the scaffold were also evaluated. The results indicated reduced swelling and degradation and enhanced biomineralization and protein adsorption. In addition, the human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells were viable, adhered and proliferated well on the alginate/bioglass composite scaffolds in comparison to the control alginate scaffolds. The presence of nBGC enhanced the alkaline phosphatase (ALP) activity of the hPDLF cells cultured on the composite scaffolds. Thus results suggest that these biocompatible composite scaffolds can be useful for periodontal tissue regeneration.</description><subject>adsorption</subject><subject>Alginate</subject><subject>Alkaline phosphatase</subject><subject>Applied sciences</subject><subject>bioactive properties</subject><subject>Bioglass</subject><subject>Biological and medical sciences</subject><subject>biomineralization</subject><subject>cell viability</subject><subject>ceramics</subject><subject>Composites</subject><subject>cultured cells</subject><subject>dentistry</subject><subject>energy-dispersive X-ray analysis</subject><subject>Exact sciences and technology</subject><subject>fibroblasts</subject><subject>Forms of application and semi-finished materials</subject><subject>Fourier transform infrared spectroscopy</subject><subject>glass</subject><subject>humans</subject><subject>ligaments</subject><subject>Medical sciences</subject><subject>Nanocomposite</subject><subject>osteosarcoma</subject><subject>Periodontal regeneration</subject><subject>Polymer industry, paints, wood</subject><subject>scanning electron microscopy</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tissue engineering</subject><subject>tissue repair</subject><subject>X-ray diffraction</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkE2LFDEQhhtRcFz9CWIugpfuTbrz1SfRxS9Y8KB7DtXpypAxk7RJZsF_b4YZvFqXujzvW8XTda8ZHRhl8vYwWMjLlsIwUsYGqgYq9JNux7SaezZx_rTbUcZ5ryVTz7sXpRxoG8norvv10SebjhtUvwQkEPY-QsXbCDGRxSew1T8i2QcohVjMcPSWnAOp-IqkWHAuhbUQlzLZMPu0plghkOpLOSHJuMfYYtWn-LJ75iAUfHXdN93D508_777299-_fLv7cN_baZa1Z8uo9Lqsik5gqRNUM6Ccq0XO06xxdsLJEaR1iErTVVBQq5rUaNtyyvLppnt36d1y-n3CUs3RF4shQMR0KmYUukkZ2SQaKi6ozamUjM5s2R8h_zGMmrNcczBXueYs11BlmtyWe3s9AU1BcBmi9eVfeORy1oLKxr25cA6SgX1uzMOPViSbf0H5dG56fyGwGXn0mE2xHqPF1We01azJ_-eXv__VniU</recordid><startdate>20120104</startdate><enddate>20120104</enddate><creator>Srinivasan, Sowmya</creator><creator>Jayasree, R.</creator><creator>Chennazhi, K.P.</creator><creator>Nair, S.V.</creator><creator>Jayakumar, R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120104</creationdate><title>Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration</title><author>Srinivasan, Sowmya ; Jayasree, R. ; Chennazhi, K.P. ; Nair, S.V. ; Jayakumar, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-1b278dbd703ac0f5081a0447b69398e9f5f62a6cfee780d50a7d7372c7d7f7c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>adsorption</topic><topic>Alginate</topic><topic>Alkaline phosphatase</topic><topic>Applied sciences</topic><topic>bioactive properties</topic><topic>Bioglass</topic><topic>Biological and medical sciences</topic><topic>biomineralization</topic><topic>cell viability</topic><topic>ceramics</topic><topic>Composites</topic><topic>cultured cells</topic><topic>dentistry</topic><topic>energy-dispersive X-ray analysis</topic><topic>Exact sciences and technology</topic><topic>fibroblasts</topic><topic>Forms of application and semi-finished materials</topic><topic>Fourier transform infrared spectroscopy</topic><topic>glass</topic><topic>humans</topic><topic>ligaments</topic><topic>Medical sciences</topic><topic>Nanocomposite</topic><topic>osteosarcoma</topic><topic>Periodontal regeneration</topic><topic>Polymer industry, paints, wood</topic><topic>scanning electron microscopy</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology of polymers</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Tissue engineering</topic><topic>tissue repair</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srinivasan, Sowmya</creatorcontrib><creatorcontrib>Jayasree, R.</creatorcontrib><creatorcontrib>Chennazhi, K.P.</creatorcontrib><creatorcontrib>Nair, S.V.</creatorcontrib><creatorcontrib>Jayakumar, R.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srinivasan, Sowmya</au><au>Jayasree, R.</au><au>Chennazhi, K.P.</au><au>Nair, S.V.</au><au>Jayakumar, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration</atitle><jtitle>Carbohydrate polymers</jtitle><date>2012-01-04</date><risdate>2012</risdate><volume>87</volume><issue>1</issue><spage>274</spage><epage>283</epage><pages>274-283</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>► In this work, we developed biocompatible alginate/nano bioglass composite scaffolds for periodontal tissue regeneration. ► This nanocomposite scaffold is biocompatible with human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells. ► The hPDLF cells also behaved as osteoblasts showing enhanced alkaline phosphatase activity.
Periodontal regeneration is of utmost importance in the field of dentistry which essentially reconstitutes and replaces the lost tooth supporting structures. For this purpose, nano bioactive glass ceramic particle (nBGC) incorporated alginate composite scaffold was fabricated and characterized using SEM, EDAX, AFM, FTIR, XRD and other methods. The swelling ability, in vitro degradation, biomineralization and cytocompatibility of the scaffold were also evaluated. The results indicated reduced swelling and degradation and enhanced biomineralization and protein adsorption. In addition, the human periodontal ligament fibroblast (hPDLF) and osteosarcoma (MG-63) cells were viable, adhered and proliferated well on the alginate/bioglass composite scaffolds in comparison to the control alginate scaffolds. The presence of nBGC enhanced the alkaline phosphatase (ALP) activity of the hPDLF cells cultured on the composite scaffolds. Thus results suggest that these biocompatible composite scaffolds can be useful for periodontal tissue regeneration.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.carbpol.2011.07.058</doi><tpages>10</tpages></addata></record> |
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| subjects | adsorption Alginate Alkaline phosphatase Applied sciences bioactive properties Bioglass Biological and medical sciences biomineralization cell viability ceramics Composites cultured cells dentistry energy-dispersive X-ray analysis Exact sciences and technology fibroblasts Forms of application and semi-finished materials Fourier transform infrared spectroscopy glass humans ligaments Medical sciences Nanocomposite osteosarcoma Periodontal regeneration Polymer industry, paints, wood scanning electron microscopy Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments Tissue engineering tissue repair X-ray diffraction |
| title | Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration |
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