Vibrio harveyi infections induce production of proinflammatory cytokines in murine peritoneal macrophages via activation of p38 MAPK and NF-κB pathways, but reversed by PI3K/AKT pathways

Vibrio harveyi is a zoonotic pathogen that can infect humans through wounds and cause severe inflammatory responses. Previous studies have reported that the Toll like receptors (TLR) mediated MAPK, AKT and NF-κB signaling pathways are involved in innate immune system resistance to pathogen invasion....

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Veröffentlicht in:	Developmental and comparative immunology 2022-02, Vol.127, p.104292-104292, Article 104292
Hauptverfasser:	Yu, Guili, Yu, Hong, Yang, Qiankun, Wang, Jinxin, Fan, Hui, Liu, Gang, Wang, Lei, Bello, Babatunde Kazeem, Zhao, Panpan, Zhang, Honggang, Dong, Jingquan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT AKT protein Animals Assaying Bacteria Cell activation Cytokines Cytokines - metabolism Enzyme-linked immunosorbent assay Humans IL-1β Immune system Immunofluorescence Infections Inflammation Innate immunity Interleukin 12 Interleukin 6 Macrophages Macrophages, Peritoneal - metabolism MAP kinase Mice NF-kappa B - metabolism NF-κB p65 NF-κB protein p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Pathogens Peritoneum Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proteins Proto-Oncogene Proteins c-akt Signal transduction Signaling TLR2 protein Toll-like receptors Tumor necrosis factor-α Vibrio Vibrio harveyi Western blotting
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