Enantioselective Tertiary Electrophile (Hetero)Benzylation: Pd‐Catalyzed Substitution of Isoprene Monoxide with Arylacetates

The enantioselective generation of quaternary carbon centers remains challenging but is of growing importance for the preparation of functional molecules. Metal catalyzed allylic alkylations of tertiary electrophiles can provide access to these substructures but remain generally incompatible with or...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-12, Vol.60 (51), p.26495-26499
Hauptverfasser:	Doyle, Michael G. J., Gabbey, Alexis L., McNutt, Wesley, Lundgren, Rylan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation benzylation Carbon Catalysts Decarboxylation Enantiomers enantioselective catalysis Functional groups Isoprene Nucleophiles Palladium quaternary stereocenters Stereoselectivity Substitution reactions
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