Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity

Methotrexate is used for cure of many cancer types. It has many side effects. For this reason, obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine probable effects of Vitamin B12 on MTX caused kidney damages in rats. Rats were randomly divided into 4 groups, inclu...

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Veröffentlicht in:	Journal of molecular histology 2022-02, Vol.53 (1), p.133-143
Hauptverfasser:	Ozturk, E., Karabulut, D., Akin, A. T., Kaymak, E., Kuloglu, N., Yakan, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antimetabolites, Antineoplastic - toxicity Antioxidants Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Cancer Catalase Catalase - metabolism Cell Biology Developmental Biology Dihydrofolate reductase Drug dosages Endoplasmic reticulum Enzyme-Linked Immunosorbent Assay Experiments Heat shock proteins Histology Histopathology Immunohistochemistry In Situ Nick-End Labeling Inflammation Interleukin 6 Interleukin-6 - metabolism Kidney Diseases - chemically induced Kidney Diseases - enzymology Kidney Diseases - prevention & control Kidneys Life Sciences Male Malondialdehyde Malondialdehyde - metabolism Methotrexate Methotrexate - toxicity Normal distribution Original Paper Oxidants Protein synthesis Rats Rats, Wistar Software Superoxide dismutase Superoxide Dismutase - metabolism Vitamin B 12 - therapeutic use Vitamin B Complex - therapeutic use Vitamin B12
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