Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity
Methotrexate is used for cure of many cancer types. It has many side effects. For this reason, obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine probable effects of Vitamin B12 on MTX caused kidney damages in rats. Rats were randomly divided into 4 groups, inclu...
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| Veröffentlicht in: | Journal of molecular histology 2022-02, Vol.53 (1), p.133-143 |
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| creator | Ozturk, E. Karabulut, D. Akin, A. T. Kaymak, E. Kuloglu, N. Yakan, B. |
| description | Methotrexate is used for cure of many cancer types. It has many side effects. For this reason, obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine probable effects of Vitamin B12 on MTX caused kidney damages in rats. Rats were randomly divided into 4 groups, including 8 animals in each group. Control group, VitB12 group (3 μg-kg-
ip
B12 throughout 15 days), MTX group (at the 8th day of experiment, a single dose of 20 mg-kg-
ip
MTX), Vit B12 + MTX group (3 μg-kg-
ip
B12 throughout 15 days and at the 8th day of experiment, a single dose of 20 mg-kg-
ip
MTX) Animals were anesthetized and kidney tissues were removed to evaluate biochemically, immunohistochemically and histopathologycally. There were histopathological deteriorations, rises of apoptotic cells, expressions of heat shock proteins, endoplasmic reticulum stress and inflammation markers in the MTX group. In the MTX group, Superoxide Dismutase (SOD), Total Antioxidant Status (TAS) and Catalase (CAT) levels decreased, but Total Oxidant Status TOS, Malondialdehyde (MDA) and interleukin
-
6 (IL6) levels increased. In addition, there was amelioration in kidney tissue in Vit B12 + MTX group compared to the MTX group. We suggest that Vit B12 can be used to reduce the toxic effects of MTX. |
| doi_str_mv | 10.1007/s10735-021-10027-9 |
| format | Article |
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ip
B12 throughout 15 days), MTX group (at the 8th day of experiment, a single dose of 20 mg-kg-
ip
MTX), Vit B12 + MTX group (3 μg-kg-
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B12 throughout 15 days and at the 8th day of experiment, a single dose of 20 mg-kg-
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MTX) Animals were anesthetized and kidney tissues were removed to evaluate biochemically, immunohistochemically and histopathologycally. There were histopathological deteriorations, rises of apoptotic cells, expressions of heat shock proteins, endoplasmic reticulum stress and inflammation markers in the MTX group. In the MTX group, Superoxide Dismutase (SOD), Total Antioxidant Status (TAS) and Catalase (CAT) levels decreased, but Total Oxidant Status TOS, Malondialdehyde (MDA) and interleukin
-
6 (IL6) levels increased. In addition, there was amelioration in kidney tissue in Vit B12 + MTX group compared to the MTX group. We suggest that Vit B12 can be used to reduce the toxic effects of MTX.</description><identifier>ISSN: 1567-2379</identifier><identifier>EISSN: 1567-2387</identifier><identifier>DOI: 10.1007/s10735-021-10027-9</identifier><identifier>PMID: 34655350</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acids ; Animals ; Antimetabolites, Antineoplastic - toxicity ; Antioxidants ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Catalase ; Catalase - metabolism ; Cell Biology ; Developmental Biology ; Dihydrofolate reductase ; Drug dosages ; Endoplasmic reticulum ; Enzyme-Linked Immunosorbent Assay ; Experiments ; Heat shock proteins ; Histology ; Histopathology ; Immunohistochemistry ; In Situ Nick-End Labeling ; Inflammation ; Interleukin 6 ; Interleukin-6 - metabolism ; Kidney Diseases - chemically induced ; Kidney Diseases - enzymology ; Kidney Diseases - prevention & control ; Kidneys ; Life Sciences ; Male ; Malondialdehyde ; Malondialdehyde - metabolism ; Methotrexate ; Methotrexate - toxicity ; Normal distribution ; Original Paper ; Oxidants ; Protein synthesis ; Rats ; Rats, Wistar ; Software ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Vitamin B 12 - therapeutic use ; Vitamin B Complex - therapeutic use ; Vitamin B12</subject><ispartof>Journal of molecular histology, 2022-02, Vol.53 (1), p.133-143</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-998644ec4784a32e76c85d491885260edcceeb7563be48019d8641cbdea0937f3</citedby><cites>FETCH-LOGICAL-c375t-998644ec4784a32e76c85d491885260edcceeb7563be48019d8641cbdea0937f3</cites><orcidid>0000-0003-2067-6174 ; 0000-0002-1408-8571 ; 0000-0002-1199-2784 ; 0000-0002-5456-4579 ; 0000-0003-0756-0329 ; 0000-0002-3818-2693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10735-021-10027-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10735-021-10027-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34655350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozturk, E.</creatorcontrib><creatorcontrib>Karabulut, D.</creatorcontrib><creatorcontrib>Akin, A. T.</creatorcontrib><creatorcontrib>Kaymak, E.</creatorcontrib><creatorcontrib>Kuloglu, N.</creatorcontrib><creatorcontrib>Yakan, B.</creatorcontrib><title>Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity</title><title>Journal of molecular histology</title><addtitle>J Mol Histol</addtitle><addtitle>J Mol Histol</addtitle><description>Methotrexate is used for cure of many cancer types. It has many side effects. For this reason, obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine probable effects of Vitamin B12 on MTX caused kidney damages in rats. Rats were randomly divided into 4 groups, including 8 animals in each group. Control group, VitB12 group (3 μg-kg-
ip
B12 throughout 15 days), MTX group (at the 8th day of experiment, a single dose of 20 mg-kg-
ip
MTX), Vit B12 + MTX group (3 μg-kg-
ip
B12 throughout 15 days and at the 8th day of experiment, a single dose of 20 mg-kg-
ip
MTX) Animals were anesthetized and kidney tissues were removed to evaluate biochemically, immunohistochemically and histopathologycally. There were histopathological deteriorations, rises of apoptotic cells, expressions of heat shock proteins, endoplasmic reticulum stress and inflammation markers in the MTX group. In the MTX group, Superoxide Dismutase (SOD), Total Antioxidant Status (TAS) and Catalase (CAT) levels decreased, but Total Oxidant Status TOS, Malondialdehyde (MDA) and interleukin
-
6 (IL6) levels increased. In addition, there was amelioration in kidney tissue in Vit B12 + MTX group compared to the MTX group. We suggest that Vit B12 can be used to reduce the toxic effects of MTX.</description><subject>Acids</subject><subject>Animals</subject><subject>Antimetabolites, Antineoplastic - toxicity</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Catalase</subject><subject>Catalase - metabolism</subject><subject>Cell Biology</subject><subject>Developmental Biology</subject><subject>Dihydrofolate reductase</subject><subject>Drug dosages</subject><subject>Endoplasmic reticulum</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Experiments</subject><subject>Heat shock proteins</subject><subject>Histology</subject><subject>Histopathology</subject><subject>Immunohistochemistry</subject><subject>In Situ Nick-End Labeling</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - metabolism</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - enzymology</subject><subject>Kidney Diseases - prevention & control</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>Methotrexate</subject><subject>Methotrexate - toxicity</subject><subject>Normal distribution</subject><subject>Original Paper</subject><subject>Oxidants</subject><subject>Protein synthesis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Software</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Vitamin B 12 - therapeutic use</subject><subject>Vitamin B Complex - therapeutic use</subject><subject>Vitamin B12</subject><issn>1567-2379</issn><issn>1567-2387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUlPwzAQhS0EYin8AQ7IEhcuAS9xbB-hYpOQuMDZcpwJddUkxXYq-u8xlEXiwGk8mm-en-YhdEzJOSVEXkRKJBcFYbTIPZOF3kL7VFSyYFzJ7Z-31HvoIMZ5ZlRV6l20x8tKCC7IPppfr-xitMkPPa7XuPFtCwH6hDtwM9v72EU8tDjNAC_DkMAlvwIMmXLpc7LyyXa-x1eU4azRQZoNKcCbTYB7WM7y0vDmnU_rQ7TT2kWEo686Qc8310_Tu-Lh8fZ-evlQOC5FKrTOJktwpVSl5Qxk5ZRoSk2VEqwi0DgHUEtR8RpKRahuMk9d3YAlmsuWT9DZRjcbfh0hJtP56GCxsD0MYzRMKKaoEpmeoNM_6HwYQ5_dGVZxke-rFckU21AuDDEGaM0y-M6GtaHEfCRhNkmYnIT5TMJ8SJ98SY91B83PyvfpM8A3QMyj_gXC79__yL4D4K-UNA</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Ozturk, E.</creator><creator>Karabulut, D.</creator><creator>Akin, A. 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T. ; Kaymak, E. ; Kuloglu, N. ; Yakan, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-998644ec4784a32e76c85d491885260edcceeb7563be48019d8641cbdea0937f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Antimetabolites, Antineoplastic - toxicity</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Catalase</topic><topic>Catalase - metabolism</topic><topic>Cell Biology</topic><topic>Developmental Biology</topic><topic>Dihydrofolate reductase</topic><topic>Drug dosages</topic><topic>Endoplasmic reticulum</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Experiments</topic><topic>Heat shock proteins</topic><topic>Histology</topic><topic>Histopathology</topic><topic>Immunohistochemistry</topic><topic>In Situ Nick-End Labeling</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - metabolism</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - enzymology</topic><topic>Kidney Diseases - prevention & control</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - metabolism</topic><topic>Methotrexate</topic><topic>Methotrexate - toxicity</topic><topic>Normal distribution</topic><topic>Original Paper</topic><topic>Oxidants</topic><topic>Protein synthesis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Software</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Vitamin B 12 - therapeutic use</topic><topic>Vitamin B Complex - therapeutic use</topic><topic>Vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozturk, E.</creatorcontrib><creatorcontrib>Karabulut, D.</creatorcontrib><creatorcontrib>Akin, A. T.</creatorcontrib><creatorcontrib>Kaymak, E.</creatorcontrib><creatorcontrib>Kuloglu, N.</creatorcontrib><creatorcontrib>Yakan, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular histology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozturk, E.</au><au>Karabulut, D.</au><au>Akin, A. T.</au><au>Kaymak, E.</au><au>Kuloglu, N.</au><au>Yakan, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity</atitle><jtitle>Journal of molecular histology</jtitle><stitle>J Mol Histol</stitle><addtitle>J Mol Histol</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>53</volume><issue>1</issue><spage>133</spage><epage>143</epage><pages>133-143</pages><issn>1567-2379</issn><eissn>1567-2387</eissn><abstract>Methotrexate is used for cure of many cancer types. It has many side effects. For this reason, obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine probable effects of Vitamin B12 on MTX caused kidney damages in rats. Rats were randomly divided into 4 groups, including 8 animals in each group. Control group, VitB12 group (3 μg-kg-
ip
B12 throughout 15 days), MTX group (at the 8th day of experiment, a single dose of 20 mg-kg-
ip
MTX), Vit B12 + MTX group (3 μg-kg-
ip
B12 throughout 15 days and at the 8th day of experiment, a single dose of 20 mg-kg-
ip
MTX) Animals were anesthetized and kidney tissues were removed to evaluate biochemically, immunohistochemically and histopathologycally. There were histopathological deteriorations, rises of apoptotic cells, expressions of heat shock proteins, endoplasmic reticulum stress and inflammation markers in the MTX group. In the MTX group, Superoxide Dismutase (SOD), Total Antioxidant Status (TAS) and Catalase (CAT) levels decreased, but Total Oxidant Status TOS, Malondialdehyde (MDA) and interleukin
-
6 (IL6) levels increased. In addition, there was amelioration in kidney tissue in Vit B12 + MTX group compared to the MTX group. We suggest that Vit B12 can be used to reduce the toxic effects of MTX.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>34655350</pmid><doi>10.1007/s10735-021-10027-9</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2067-6174</orcidid><orcidid>https://orcid.org/0000-0002-1408-8571</orcidid><orcidid>https://orcid.org/0000-0002-1199-2784</orcidid><orcidid>https://orcid.org/0000-0002-5456-4579</orcidid><orcidid>https://orcid.org/0000-0003-0756-0329</orcidid><orcidid>https://orcid.org/0000-0002-3818-2693</orcidid></addata></record> |
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| ispartof | Journal of molecular histology, 2022-02, Vol.53 (1), p.133-143 |
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| subjects | Acids Animals Antimetabolites, Antineoplastic - toxicity Antioxidants Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Cancer Catalase Catalase - metabolism Cell Biology Developmental Biology Dihydrofolate reductase Drug dosages Endoplasmic reticulum Enzyme-Linked Immunosorbent Assay Experiments Heat shock proteins Histology Histopathology Immunohistochemistry In Situ Nick-End Labeling Inflammation Interleukin 6 Interleukin-6 - metabolism Kidney Diseases - chemically induced Kidney Diseases - enzymology Kidney Diseases - prevention & control Kidneys Life Sciences Male Malondialdehyde Malondialdehyde - metabolism Methotrexate Methotrexate - toxicity Normal distribution Original Paper Oxidants Protein synthesis Rats Rats, Wistar Software Superoxide dismutase Superoxide Dismutase - metabolism Vitamin B 12 - therapeutic use Vitamin B Complex - therapeutic use Vitamin B12 |
| title | Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity |
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