Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism was shown to strongly affect BDNF function, but its role in modulating gray matter damage in multiple sclerosis (MS) patients is still not clear. Given BDNF relevance on the hippocampus, we aimed to explore BDNF Val66Met polymorphism eff...
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| Veröffentlicht in: | Molecular psychiatry 2022-02, Vol.27 (2), p.1010-1019 |
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| creator | De Meo, Ermelinda Portaccio, Emilio Prestipino, Elio Nacmias, Benedetta Bagnoli, Silvia Razzolini, Lorenzo Pastò, Luisa Niccolai, Claudia Goretti, Benedetta Bellinvia, Angelo Fonderico, Mattia Giorgio, Antonio Stromillo, Maria Laura Filippi, Massimo Sorbi, Sandro De Stefano, Nicola Amato, Maria Pia |
| description | Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism was shown to strongly affect BDNF function, but its role in modulating gray matter damage in multiple sclerosis (MS) patients is still not clear. Given BDNF relevance on the hippocampus, we aimed to explore BDNF Val66Met polymorphism effect on hippocampal subfield volumes and its role in cognitive functioning in MS patients. Using a 3T scanner, we obtained dual-echo and 3DT1-weighted sequences from 50 MS patients and 15 healthy controls (HC) consecutively enrolled. MS patients also underwent genotype analysis of BDNF, neurological and neuropsychological evaluation. Hippocampal subfields were segmented by using Freesurfer. The BDNF Val66Met polymorphism was found in 22 MS patients (44%). Compared to HC, MS patients had lower volume in: bilateral hippocampus-amygdala transition area (HATA); cornus ammonis (CA)1, granule cell layer of dentate gyrus (GCL-DG), CA4 and CA3 of the left hippocampal head; molecular layer (ML) of the left hippocampal body; presubiculum of right hippocampal body and right fimbria. Compared to BDNF Val66Val, Val66Met MS patients had higher volume in bilateral hippocampal tail; CA1, ML, CA3, CA4, and GCL-DG of left hippocampal head; CA1, ML, and CA3 of the left hippocampal body; left HATA and presubiculum of the right hippocampal head. In MS patients, higher lesion burden was associated with lower volume of presubiculum of right hippocampal body; lower volume of left hippocampal tail was associated with worse visuospatial memory performance; lower volume of left hippocampal head with worse performance in semantic fluency. Our findings suggest the BNDF Val66Met polymorphism may have a protective role in MS patients against both hippocampal atrophy and cognitive impairment. BDNF genotype might be a potential biomarker for predicting cognitive prognosis, and an interesting target to study for neuroprotective strategies. |
| doi_str_mv | 10.1038/s41380-021-01345-1 |
| format | Article |
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Given BDNF relevance on the hippocampus, we aimed to explore BDNF Val66Met polymorphism effect on hippocampal subfield volumes and its role in cognitive functioning in MS patients. Using a 3T scanner, we obtained dual-echo and 3DT1-weighted sequences from 50 MS patients and 15 healthy controls (HC) consecutively enrolled. MS patients also underwent genotype analysis of BDNF, neurological and neuropsychological evaluation. Hippocampal subfields were segmented by using Freesurfer. The BDNF Val66Met polymorphism was found in 22 MS patients (44%). Compared to HC, MS patients had lower volume in: bilateral hippocampus-amygdala transition area (HATA); cornus ammonis (CA)1, granule cell layer of dentate gyrus (GCL-DG), CA4 and CA3 of the left hippocampal head; molecular layer (ML) of the left hippocampal body; presubiculum of right hippocampal body and right fimbria. Compared to BDNF Val66Val, Val66Met MS patients had higher volume in bilateral hippocampal tail; CA1, ML, CA3, CA4, and GCL-DG of left hippocampal head; CA1, ML, and CA3 of the left hippocampal body; left HATA and presubiculum of the right hippocampal head. In MS patients, higher lesion burden was associated with lower volume of presubiculum of right hippocampal body; lower volume of left hippocampal tail was associated with worse visuospatial memory performance; lower volume of left hippocampal head with worse performance in semantic fluency. Our findings suggest the BNDF Val66Met polymorphism may have a protective role in MS patients against both hippocampal atrophy and cognitive impairment. BDNF genotype might be a potential biomarker for predicting cognitive prognosis, and an interesting target to study for neuroprotective strategies.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-021-01345-1</identifier><identifier>PMID: 34650209</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38 ; 45/77 ; 59/57 ; 631/208 ; 631/378 ; 631/477 ; 692/53/2422 ; Amygdala ; Atrophy ; Atrophy - pathology ; Behavioral Sciences ; Biological Psychology ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Cognitive ability ; Cognitive Dysfunction - pathology ; Dentate gyrus ; Fornix ; Gene polymorphism ; Head ; Hippocampus ; Hippocampus - diagnostic imaging ; Hippocampus - pathology ; Humans ; Magnetic Resonance Imaging ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Multiple Sclerosis - genetics ; Multiple Sclerosis - pathology ; Neuroprotection ; Neurosciences ; Pharmacotherapy ; Polymorphism ; Presubiculum ; Psychiatry ; Spatial memory ; Statins ; Substantia grisea</subject><ispartof>Molecular psychiatry, 2022-02, Vol.27 (2), p.1010-1019</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-d33b6366e9c3f427c8564b0067322288acd2ed09ab075e8dbee94d91f5a802253</citedby><cites>FETCH-LOGICAL-c375t-d33b6366e9c3f427c8564b0067322288acd2ed09ab075e8dbee94d91f5a802253</cites><orcidid>0000-0001-5531-1111 ; 0000-0002-9662-1762 ; 0000-0001-9338-9040 ; 0000-0002-5485-0479</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41380-021-01345-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41380-021-01345-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34650209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Meo, Ermelinda</creatorcontrib><creatorcontrib>Portaccio, Emilio</creatorcontrib><creatorcontrib>Prestipino, Elio</creatorcontrib><creatorcontrib>Nacmias, Benedetta</creatorcontrib><creatorcontrib>Bagnoli, Silvia</creatorcontrib><creatorcontrib>Razzolini, Lorenzo</creatorcontrib><creatorcontrib>Pastò, Luisa</creatorcontrib><creatorcontrib>Niccolai, Claudia</creatorcontrib><creatorcontrib>Goretti, Benedetta</creatorcontrib><creatorcontrib>Bellinvia, Angelo</creatorcontrib><creatorcontrib>Fonderico, Mattia</creatorcontrib><creatorcontrib>Giorgio, Antonio</creatorcontrib><creatorcontrib>Stromillo, Maria Laura</creatorcontrib><creatorcontrib>Filippi, Massimo</creatorcontrib><creatorcontrib>Sorbi, Sandro</creatorcontrib><creatorcontrib>De Stefano, Nicola</creatorcontrib><creatorcontrib>Amato, Maria Pia</creatorcontrib><title>Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism was shown to strongly affect BDNF function, but its role in modulating gray matter damage in multiple sclerosis (MS) patients is still not clear. Given BDNF relevance on the hippocampus, we aimed to explore BDNF Val66Met polymorphism effect on hippocampal subfield volumes and its role in cognitive functioning in MS patients. Using a 3T scanner, we obtained dual-echo and 3DT1-weighted sequences from 50 MS patients and 15 healthy controls (HC) consecutively enrolled. MS patients also underwent genotype analysis of BDNF, neurological and neuropsychological evaluation. Hippocampal subfields were segmented by using Freesurfer. The BDNF Val66Met polymorphism was found in 22 MS patients (44%). Compared to HC, MS patients had lower volume in: bilateral hippocampus-amygdala transition area (HATA); cornus ammonis (CA)1, granule cell layer of dentate gyrus (GCL-DG), CA4 and CA3 of the left hippocampal head; molecular layer (ML) of the left hippocampal body; presubiculum of right hippocampal body and right fimbria. Compared to BDNF Val66Val, Val66Met MS patients had higher volume in bilateral hippocampal tail; CA1, ML, CA3, CA4, and GCL-DG of left hippocampal head; CA1, ML, and CA3 of the left hippocampal body; left HATA and presubiculum of the right hippocampal head. In MS patients, higher lesion burden was associated with lower volume of presubiculum of right hippocampal body; lower volume of left hippocampal tail was associated with worse visuospatial memory performance; lower volume of left hippocampal head with worse performance in semantic fluency. Our findings suggest the BNDF Val66Met polymorphism may have a protective role in MS patients against both hippocampal atrophy and cognitive impairment. BDNF genotype might be a potential biomarker for predicting cognitive prognosis, and an interesting target to study for neuroprotective strategies.</description><subject>38</subject><subject>45/77</subject><subject>59/57</subject><subject>631/208</subject><subject>631/378</subject><subject>631/477</subject><subject>692/53/2422</subject><subject>Amygdala</subject><subject>Atrophy</subject><subject>Atrophy - pathology</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - pathology</subject><subject>Dentate gyrus</subject><subject>Fornix</subject><subject>Gene polymorphism</subject><subject>Head</subject><subject>Hippocampus</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - genetics</subject><subject>Multiple Sclerosis - pathology</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Pharmacotherapy</subject><subject>Polymorphism</subject><subject>Presubiculum</subject><subject>Psychiatry</subject><subject>Spatial memory</subject><subject>Statins</subject><subject>Substantia grisea</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kDtP3jAUhi1UBBT4AwyVpS4sob7bGSmXgsRlASYky3FOipETu3Ey8O_Jx0eLxNDJlt7Hr895EDqg5IgSbn4UQbkhFWG0IpQLWdENtEOFVpWU2nxZ7lzWlaBGbKOvpTwTsgrlFtrmQknCSL2DHs-6DvyEU4d_nt6c4wcXlbqGCecUX_o05qdQepwG_BRyTt712UVc5qYLENuCw4D7OU4hR8DFRxhTCQVnNwUYprKHNjsXC-y_n7vo_vzs7uSiurr9dXlyfFV5ruVUtZw3iisFteedYNobqURDiNKcMWaM8y2DltSuIVqCaRuAWrQ17aQzhDHJd9HhujeP6c8MZbJ9KB5idAOkuVgmDTNU1pou6PdP6HOax2GZzjIlVa21JGah2Jryy0JlhM7mMfRufLGU2JV7u3ZvF_f2zb1dVX97r56bHtp_T_7KXgC-BsoSDb9h_Pj7P7WvBjiOGQ</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>De Meo, Ermelinda</creator><creator>Portaccio, Emilio</creator><creator>Prestipino, Elio</creator><creator>Nacmias, Benedetta</creator><creator>Bagnoli, Silvia</creator><creator>Razzolini, Lorenzo</creator><creator>Pastò, Luisa</creator><creator>Niccolai, Claudia</creator><creator>Goretti, Benedetta</creator><creator>Bellinvia, Angelo</creator><creator>Fonderico, Mattia</creator><creator>Giorgio, Antonio</creator><creator>Stromillo, Maria Laura</creator><creator>Filippi, Massimo</creator><creator>Sorbi, Sandro</creator><creator>De Stefano, Nicola</creator><creator>Amato, Maria Pia</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5531-1111</orcidid><orcidid>https://orcid.org/0000-0002-9662-1762</orcidid><orcidid>https://orcid.org/0000-0001-9338-9040</orcidid><orcidid>https://orcid.org/0000-0002-5485-0479</orcidid></search><sort><creationdate>20220201</creationdate><title>Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients</title><author>De Meo, Ermelinda ; Portaccio, Emilio ; Prestipino, Elio ; Nacmias, Benedetta ; Bagnoli, Silvia ; Razzolini, Lorenzo ; Pastò, Luisa ; Niccolai, Claudia ; Goretti, Benedetta ; Bellinvia, Angelo ; Fonderico, Mattia ; Giorgio, Antonio ; Stromillo, Maria Laura ; Filippi, Massimo ; Sorbi, Sandro ; De Stefano, Nicola ; Amato, Maria Pia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-d33b6366e9c3f427c8564b0067322288acd2ed09ab075e8dbee94d91f5a802253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>38</topic><topic>45/77</topic><topic>59/57</topic><topic>631/208</topic><topic>631/378</topic><topic>631/477</topic><topic>692/53/2422</topic><topic>Amygdala</topic><topic>Atrophy</topic><topic>Atrophy - pathology</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - pathology</topic><topic>Dentate gyrus</topic><topic>Fornix</topic><topic>Gene polymorphism</topic><topic>Head</topic><topic>Hippocampus</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - genetics</topic><topic>Multiple Sclerosis - pathology</topic><topic>Neuroprotection</topic><topic>Neurosciences</topic><topic>Pharmacotherapy</topic><topic>Polymorphism</topic><topic>Presubiculum</topic><topic>Psychiatry</topic><topic>Spatial memory</topic><topic>Statins</topic><topic>Substantia grisea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Meo, Ermelinda</creatorcontrib><creatorcontrib>Portaccio, Emilio</creatorcontrib><creatorcontrib>Prestipino, Elio</creatorcontrib><creatorcontrib>Nacmias, Benedetta</creatorcontrib><creatorcontrib>Bagnoli, Silvia</creatorcontrib><creatorcontrib>Razzolini, Lorenzo</creatorcontrib><creatorcontrib>Pastò, Luisa</creatorcontrib><creatorcontrib>Niccolai, Claudia</creatorcontrib><creatorcontrib>Goretti, Benedetta</creatorcontrib><creatorcontrib>Bellinvia, Angelo</creatorcontrib><creatorcontrib>Fonderico, Mattia</creatorcontrib><creatorcontrib>Giorgio, Antonio</creatorcontrib><creatorcontrib>Stromillo, Maria Laura</creatorcontrib><creatorcontrib>Filippi, Massimo</creatorcontrib><creatorcontrib>Sorbi, Sandro</creatorcontrib><creatorcontrib>De Stefano, Nicola</creatorcontrib><creatorcontrib>Amato, Maria Pia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Meo, Ermelinda</au><au>Portaccio, Emilio</au><au>Prestipino, Elio</au><au>Nacmias, Benedetta</au><au>Bagnoli, Silvia</au><au>Razzolini, Lorenzo</au><au>Pastò, Luisa</au><au>Niccolai, Claudia</au><au>Goretti, Benedetta</au><au>Bellinvia, Angelo</au><au>Fonderico, Mattia</au><au>Giorgio, Antonio</au><au>Stromillo, Maria Laura</au><au>Filippi, Massimo</au><au>Sorbi, Sandro</au><au>De Stefano, Nicola</au><au>Amato, Maria Pia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>27</volume><issue>2</issue><spage>1010</spage><epage>1019</epage><pages>1010-1019</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism was shown to strongly affect BDNF function, but its role in modulating gray matter damage in multiple sclerosis (MS) patients is still not clear. Given BDNF relevance on the hippocampus, we aimed to explore BDNF Val66Met polymorphism effect on hippocampal subfield volumes and its role in cognitive functioning in MS patients. Using a 3T scanner, we obtained dual-echo and 3DT1-weighted sequences from 50 MS patients and 15 healthy controls (HC) consecutively enrolled. MS patients also underwent genotype analysis of BDNF, neurological and neuropsychological evaluation. Hippocampal subfields were segmented by using Freesurfer. The BDNF Val66Met polymorphism was found in 22 MS patients (44%). Compared to HC, MS patients had lower volume in: bilateral hippocampus-amygdala transition area (HATA); cornus ammonis (CA)1, granule cell layer of dentate gyrus (GCL-DG), CA4 and CA3 of the left hippocampal head; molecular layer (ML) of the left hippocampal body; presubiculum of right hippocampal body and right fimbria. Compared to BDNF Val66Val, Val66Met MS patients had higher volume in bilateral hippocampal tail; CA1, ML, CA3, CA4, and GCL-DG of left hippocampal head; CA1, ML, and CA3 of the left hippocampal body; left HATA and presubiculum of the right hippocampal head. In MS patients, higher lesion burden was associated with lower volume of presubiculum of right hippocampal body; lower volume of left hippocampal tail was associated with worse visuospatial memory performance; lower volume of left hippocampal head with worse performance in semantic fluency. Our findings suggest the BNDF Val66Met polymorphism may have a protective role in MS patients against both hippocampal atrophy and cognitive impairment. BDNF genotype might be a potential biomarker for predicting cognitive prognosis, and an interesting target to study for neuroprotective strategies.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34650209</pmid><doi>10.1038/s41380-021-01345-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5531-1111</orcidid><orcidid>https://orcid.org/0000-0002-9662-1762</orcidid><orcidid>https://orcid.org/0000-0001-9338-9040</orcidid><orcidid>https://orcid.org/0000-0002-5485-0479</orcidid></addata></record> |
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| ispartof | Molecular psychiatry, 2022-02, Vol.27 (2), p.1010-1019 |
| issn | 1359-4184 1476-5578 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 38 45/77 59/57 631/208 631/378 631/477 692/53/2422 Amygdala Atrophy Atrophy - pathology Behavioral Sciences Biological Psychology Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Cognitive ability Cognitive Dysfunction - pathology Dentate gyrus Fornix Gene polymorphism Head Hippocampus Hippocampus - diagnostic imaging Hippocampus - pathology Humans Magnetic Resonance Imaging Medicine Medicine & Public Health Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - pathology Neuroprotection Neurosciences Pharmacotherapy Polymorphism Presubiculum Psychiatry Spatial memory Statins Substantia grisea |
| title | Effect of BDNF Val66Met polymorphism on hippocampal subfields in multiple sclerosis patients |
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