AMPK promotes antitumor immunity by downregulating PD-1 in regulatory T cells via the HMGCR/p38 signaling pathway

Background AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy homeostasis. AMPK functions as a tumor suppressor in different cancers; however, its role in regulating antitumor immunity, particularly the function of regulatory T cells (Tregs), is poorly defined. Methods A...

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Veröffentlicht in:	Molecular cancer 2021-10, Vol.20 (1), p.133-133, Article 133
Hauptverfasser:	Pokhrel, Ram Hari, Acharya, Suman, Ahn, Jae-Hee, Gu, Ye, Pandit, Mahesh, Kim, Jong-Oh, Park, Yun-Yong, Kang, Ben, Ko, Hyun-Jeong, Chang, Jae-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated protein kinase AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism AMPK Animal models Animals Antibodies Antitumor activity Apoptosis Biochemistry & Molecular Biology Biotechnology Cancer therapies Cell death Cell Line, Tumor Cloning Compound C CTLA-4 protein Cytotoxicity Disease Models, Animal Disease Progression Energy balance Energy Metabolism Enzymes Fatty acids Flow cytometry Fluorescence Gene Expression Regulation Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - metabolism Glycolysis HMGCR Homeostasis Humans Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Hydroxymethylglutaryl-CoA reductase Immunity Immunomodulation Immunophenotyping Immunoregulation Kinases Life Sciences & Biomedicine Lymphatic system Lymphocytes Lymphocytes T MAP kinase Melanoma Metabolism Mevalonate pathway Mevalonic acid Mice Mitogens Oncology p38 Mitogen-Activated Protein Kinases - metabolism PD-1 PD-1 protein Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Protein kinases Proteins RAG1 protein Science & Technology Signal Transduction Synthesis T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tregs Tumor Tumor suppressor genes Tumors Viral antibodies Western blotting
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