Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities

[Display omitted] •A series of novel quinazolinyl-containing benzamides derivatives were designed.•Compounds 11a selectively inhibited HDAC1 over the other HDACs isoforms.•11a inhibited proliferation of several human cancer cells.•11a had acceptable safety and oral pharmacokinetic properties.•11a sh...

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