Efficient preparation of (R)‐2‐(2,5‐difluorophenyl)pyrrolidine via a recycle process of resolution

An efficient preparation of (R)‐2‐(2,5‐difluorophenyl)pyrrolidine ((R)‐1) from the racemate based on a recycle process of resolution/racemization was described. In the process, the desired (R)‐1 was obtained by resolution with D‐malic acid in 95% EtOH. Meanwhile, the undesired (S)‐1 could be racemiz...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2021-12, Vol.33 (12), p.931-937
Hauptverfasser:	Lv, Xunlei, Chen, Liang, Pan, Jing, Meng, Xue, Bi, Siju, Liu, Weiyuan, Zhou, Ting, Lin, Kuaile, Ye, Deyong, Zhou, Weicheng
Format:	Artikel
Sprache:	eng
Schlagworte:	(R)‐2‐(2,5‐difluorophenyl)pyrrolidine Larotrectinib Malic acid Potassium Potassium hydroxide Potassium hydroxides Pyrrolidine Racemization
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