The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation

Diets high in cholesterol alter intestinal immunity. Here, we examined how the cholesterol metabolite 25-hydroxycholesterol (25-HC) impacts the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase (CH25H), the enzyme generating 25-HC, had higher frequencies of immunoglobulin A (IgA)-s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-10, Vol.54 (10), p.2273-2287.e6
Hauptverfasser:	Trindade, Bruno C., Ceglia, Simona, Berthelette, Alyssa, Raso, Fiona, Howley, Kelsey, Muppidi, Jagan R., Reboldi, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	25-hydroxycholesterol Animals Cell Differentiation - immunology Cholesterol, Dietary - immunology Cholesterol, Dietary - metabolism dietary cholesterol follicular dendritic cells Hydroxycholesterols - immunology Hydroxycholesterols - metabolism immunoglobulin A Immunoglobulin A - immunology Immunoglobulin A - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Mice Peyer's patches Peyer's Patches - immunology Peyer's Patches - metabolism plasma cells Plasma Cells - immunology Plasma Cells - metabolism Sterol Regulatory Element Binding Protein 2 - metabolism sterol response element binding proteins 2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!