Orotic acid production by Yarrowia lipolytica under conditions of limited pyrimidine

Orotic acid (OA) is an intermediate of the pyrimidine biosynthesis with high industrial relevance due to its use as precursor for production of biochemical pyrimidines or its use as carrier molecule in drug formulations. It can be produced by fermentation of microorganisms with engineered pyrimidine...

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Veröffentlicht in:	Yeast (Chichester, England) England), 2022-03, Vol.39 (3), p.230-240
Hauptverfasser:	Swietalski, Paul, Hetzel, Frank, Klaiber, Iris, Pross, Eva, Seitl, Ines, Fischer, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid production Ammonium Ammonium sulfate Bioreactors CRISPR/Cas9 Decarboxylation Fermentation Gene deletion Metabolic engineering Metabolic pathways Metabolism Orotic acid PO1f Productivity pyrimidine limitation Pyrimidines Secretion Supplements URA3 URA3 gene Uracil Uridine Yarrowia lipolytica
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