HPV-driven anal neoplasia: review and recent developments
A host of human papillomavirus (HPV)-associated squamous and glandular lesions may be identified in the anal canal in men and women. Given their relative rarity, familiarity with the morphological spectrum associated with HPV-driven anal neoplasia is important for proper identification and diagnosis...
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| Veröffentlicht in: | Pathology 2022-03, Vol.54 (2), p.184-194 |
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| container_title | Pathology |
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| creator | Assarzadegan, Naziheh Brooks, Eugene Voltaggio, Lysandra |
| description | A host of human papillomavirus (HPV)-associated squamous and glandular lesions may be identified in the anal canal in men and women. Given their relative rarity, familiarity with the morphological spectrum associated with HPV-driven anal neoplasia is important for proper identification and diagnosis. In this article, we review the classification and basic histopathological features of HPV-related squamous intraepithelial and invasive lesions as well as associated pitfalls. In addition, we provide an update on recently described HPV-driven, non-squamous tumours. As our experience with these lesions evolves, we expect the histological spectrum to further expand, particularly as it relates to non-squamous HPV-driven neoplasia. |
| doi_str_mv | 10.1016/j.pathol.2021.07.003 |
| format | Article |
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| ispartof | Pathology, 2022-03, Vol.54 (2), p.184-194 |
| issn | 0031-3025 1465-3931 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alphapapillomavirus Anal Canal - anatomy & histology Anal Canal - pathology anal cancer Anus Neoplasms - diagnosis Anus Neoplasms - pathology Anus Neoplasms - virology Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Diagnosis, Differential Human papillomavirus Humans Papillomavirus Infections - complications Papillomavirus Infections - pathology |
| title | HPV-driven anal neoplasia: review and recent developments |
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