Electroanalysis of Enzyme Activity in Small Biological Samples: Alkaline Phosphatase

The discovery of sulfite-stabilized anodic current of hydroquinone (HQ) at high pH was used to develop two new methods for measuring the activity of the key biomarker alkaline phosphatase (ALP). Both approaches relied on the monitoring of ALP-triggered release of HQ from a substrate hydroquinone dip...

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Veröffentlicht in:	Analytical chemistry (Washington) 2021-10, Vol.93 (42), p.14280-14286
Hauptverfasser:	Bekhit, Michael, Blazek, Teresa, Gorski, Waldemar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Analytical chemistry Assaying Biological activity Biological properties Biological samples Biomarkers Chemistry Coulometers Electroanalysis Electrochemistry Electrodes Electrolytic analysis Enzymatic activity Enzyme activity Enzymes Glassy carbon Glucose Guanylate cyclase Hydroquinone Measurement methods pH effects Phosphatase Room temperature Signal reconstruction Substrates Sulfite
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