Prostatic Rhabdomyoma in a Toddler: A Case Report With Molecular Characterization
We present a 29-month-old male patient in follow-up due to pyelocaliceal dilation with a prostatic nodule incidentally found during ultrasound evaluation. Cysto video endoscopy was performed and a prostate biopsy, obtained. Microscopic evaluation showed a haphazardly distributed population of muscul...
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| Veröffentlicht in: | Pediatric and developmental pathology 2022-03, Vol.25 (2), p.203-206 |
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| container_title | Pediatric and developmental pathology |
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| creator | De la Iglesia Niveyro, Paola X. Pandolfi, J. Jauk, F. Kreindel, T. Lobos, P. |
| description | We present a 29-month-old male patient in follow-up due to pyelocaliceal dilation with a prostatic nodule incidentally found during ultrasound evaluation. Cysto video endoscopy was performed and a prostate biopsy, obtained. Microscopic evaluation showed a haphazardly distributed population of muscular cells with cross striations without evidence of mitosis or necrosis. Immunohistochemistry was positive for myogenin and desmin and negative for smooth muscle actin. Next generation sequencing was performed without finding any pathogenic variant or fusion in the tumor RNA. The patient received no further treatment, remained asymptomatic and continues in follow up, 3 years after initial diagnosis. We report a case of prostate rhabdomyoma in a toddler, an exceptional location that raises concern about differential diagnosis with its malignant counterpart, rhabdomyosarcoma, especially at this age. |
| doi_str_mv | 10.1177/10935266211046926 |
| format | Article |
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Cysto video endoscopy was performed and a prostate biopsy, obtained. Microscopic evaluation showed a haphazardly distributed population of muscular cells with cross striations without evidence of mitosis or necrosis. Immunohistochemistry was positive for myogenin and desmin and negative for smooth muscle actin. Next generation sequencing was performed without finding any pathogenic variant or fusion in the tumor RNA. The patient received no further treatment, remained asymptomatic and continues in follow up, 3 years after initial diagnosis. We report a case of prostate rhabdomyoma in a toddler, an exceptional location that raises concern about differential diagnosis with its malignant counterpart, rhabdomyosarcoma, especially at this age.</description><identifier>ISSN: 1093-5266</identifier><identifier>EISSN: 1615-5742</identifier><identifier>DOI: 10.1177/10935266211046926</identifier><identifier>PMID: 34641703</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Biopsy ; Child, Preschool ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Male ; Prostate - pathology ; Rhabdomyoma - diagnosis ; Rhabdomyoma - genetics ; Rhabdomyoma - pathology ; Rhabdomyosarcoma - diagnosis ; Rhabdomyosarcoma - genetics</subject><ispartof>Pediatric and developmental pathology, 2022-03, Vol.25 (2), p.203-206</ispartof><rights>2021, Society for Pediatric Pathology All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-10dcfdbddc0e3efc528e14b9e330c789ff2a8d9f04ca24dc7efb8f8fc53bf2963</citedby><cites>FETCH-LOGICAL-c340t-10dcfdbddc0e3efc528e14b9e330c789ff2a8d9f04ca24dc7efb8f8fc53bf2963</cites><orcidid>0000-0002-9624-6122</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10935266211046926$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10935266211046926$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34641703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De la Iglesia Niveyro, Paola X.</creatorcontrib><creatorcontrib>Pandolfi, J.</creatorcontrib><creatorcontrib>Jauk, F.</creatorcontrib><creatorcontrib>Kreindel, T.</creatorcontrib><creatorcontrib>Lobos, P.</creatorcontrib><title>Prostatic Rhabdomyoma in a Toddler: A Case Report With Molecular Characterization</title><title>Pediatric and developmental pathology</title><addtitle>Pediatr Dev Pathol</addtitle><description>We present a 29-month-old male patient in follow-up due to pyelocaliceal dilation with a prostatic nodule incidentally found during ultrasound evaluation. Cysto video endoscopy was performed and a prostate biopsy, obtained. Microscopic evaluation showed a haphazardly distributed population of muscular cells with cross striations without evidence of mitosis or necrosis. Immunohistochemistry was positive for myogenin and desmin and negative for smooth muscle actin. Next generation sequencing was performed without finding any pathogenic variant or fusion in the tumor RNA. The patient received no further treatment, remained asymptomatic and continues in follow up, 3 years after initial diagnosis. We report a case of prostate rhabdomyoma in a toddler, an exceptional location that raises concern about differential diagnosis with its malignant counterpart, rhabdomyosarcoma, especially at this age.</description><subject>Biopsy</subject><subject>Child, Preschool</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Prostate - pathology</subject><subject>Rhabdomyoma - diagnosis</subject><subject>Rhabdomyoma - genetics</subject><subject>Rhabdomyoma - pathology</subject><subject>Rhabdomyosarcoma - diagnosis</subject><subject>Rhabdomyosarcoma - genetics</subject><issn>1093-5266</issn><issn>1615-5742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EolD4ADbISzYpfiROwq6KeElFQFXEMnLsMU2VxMVOFuXrcdXCBonVjDTnHmkuQheUTChN02tKcp4wIRilJBY5EwfohAqaREkas8Owh3u0BUbo1PsVISEkyDEa8VjENCX8BL2-OOt72dcKz5ey0rbd2FbiusMSL6zWDbgbPMWF9IDnsLaux-91v8RPtgE1NNLhYimdVD24-itobHeGjoxsPJzv5xi93d0uiodo9nz_WExnkeIx6SNKtDK60loR4GBUwjKgcZUD50SlWW4Mk5nODYmVZLFWKZgqM1kAeWVYLvgYXe28a2c_B_B92dZeQdPIDuzgS5ZkNGOUiCSgdIeq8Kx3YMq1q1vpNiUl5bbJ8k-TIXO51w9VC_o38VNdACY7wMsPKFd2cF149x_jN09ee-w</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>De la Iglesia Niveyro, Paola X.</creator><creator>Pandolfi, J.</creator><creator>Jauk, F.</creator><creator>Kreindel, T.</creator><creator>Lobos, P.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9624-6122</orcidid></search><sort><creationdate>20220301</creationdate><title>Prostatic Rhabdomyoma in a Toddler: A Case Report With Molecular Characterization</title><author>De la Iglesia Niveyro, Paola X. ; Pandolfi, J. ; Jauk, F. ; Kreindel, T. ; Lobos, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-10dcfdbddc0e3efc528e14b9e330c789ff2a8d9f04ca24dc7efb8f8fc53bf2963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biopsy</topic><topic>Child, Preschool</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Prostate - pathology</topic><topic>Rhabdomyoma - diagnosis</topic><topic>Rhabdomyoma - genetics</topic><topic>Rhabdomyoma - pathology</topic><topic>Rhabdomyosarcoma - diagnosis</topic><topic>Rhabdomyosarcoma - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De la Iglesia Niveyro, Paola X.</creatorcontrib><creatorcontrib>Pandolfi, J.</creatorcontrib><creatorcontrib>Jauk, F.</creatorcontrib><creatorcontrib>Kreindel, T.</creatorcontrib><creatorcontrib>Lobos, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric and developmental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De la Iglesia Niveyro, Paola X.</au><au>Pandolfi, J.</au><au>Jauk, F.</au><au>Kreindel, T.</au><au>Lobos, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostatic Rhabdomyoma in a Toddler: A Case Report With Molecular Characterization</atitle><jtitle>Pediatric and developmental pathology</jtitle><addtitle>Pediatr Dev Pathol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>25</volume><issue>2</issue><spage>203</spage><epage>206</epage><pages>203-206</pages><issn>1093-5266</issn><eissn>1615-5742</eissn><abstract>We present a 29-month-old male patient in follow-up due to pyelocaliceal dilation with a prostatic nodule incidentally found during ultrasound evaluation. Cysto video endoscopy was performed and a prostate biopsy, obtained. Microscopic evaluation showed a haphazardly distributed population of muscular cells with cross striations without evidence of mitosis or necrosis. Immunohistochemistry was positive for myogenin and desmin and negative for smooth muscle actin. Next generation sequencing was performed without finding any pathogenic variant or fusion in the tumor RNA. The patient received no further treatment, remained asymptomatic and continues in follow up, 3 years after initial diagnosis. We report a case of prostate rhabdomyoma in a toddler, an exceptional location that raises concern about differential diagnosis with its malignant counterpart, rhabdomyosarcoma, especially at this age.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>34641703</pmid><doi>10.1177/10935266211046926</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9624-6122</orcidid></addata></record> |
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| ispartof | Pediatric and developmental pathology, 2022-03, Vol.25 (2), p.203-206 |
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| language | eng |
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| subjects | Biopsy Child, Preschool Diagnosis, Differential Humans Immunohistochemistry Male Prostate - pathology Rhabdomyoma - diagnosis Rhabdomyoma - genetics Rhabdomyoma - pathology Rhabdomyosarcoma - diagnosis Rhabdomyosarcoma - genetics |
| title | Prostatic Rhabdomyoma in a Toddler: A Case Report With Molecular Characterization |
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