Pharmacokinetic and excretion study of eight active constituents in rat by LC-MS/MS after oral administration of the Toddalia asiatica extract

Toddalia asiatica L., a significant medicinal plant in the family Rutaceae, has been applied to treat rheumatoid diseases for decades. Its pharmacological activities are mainly attributed to the existence of generous coumarins and alkaloids; however, the pharmacokinetics of Toddalia asiatica L. rema...

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Veröffentlicht in:	Analytical biochemistry 2022-03, Vol.640, p.114407, Article 114407
Hauptverfasser:	Qiu, Jingwen, Zhu, Mingjuan, Wang, Ying, Chen, Bingying, Bai, Rongyu, Chen, Fenglian, Li, Yu, Zhou, Yuan, Zhang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alkaloids Alkaloids - pharmacokinetics Animals Chromatography, High Pressure Liquid - methods Coumarin Coumarins - blood Coumarins - chemistry Coumarins - pharmacokinetics Excretion study Feces - chemistry Flavonoid Flavonoids - analysis Flavonoids - blood Flavonoids - pharmacokinetics Flavonoids - urine LC-MS/MS Liquid Chromatography-Mass Spectrometry Male Pharmacokinetics Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacokinetics Rats Rats, Sprague-Dawley Rutaceae - chemistry Tandem Mass Spectrometry - methods Toddalia asiatica
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