Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-throughput, single-cell assessment of heterochromatin and its underlying genomic determinants remains challenging. We engineered a hybrid transposase including the chromodomain (CD) of the heterochromatin pr...

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Veröffentlicht in:	Nature biotechnology 2022-02, Vol.40 (2), p.235-244
Hauptverfasser:	Tedesco, Martina, Giannese, Francesca, Lazarević, Dejan, Giansanti, Valentina, Rosano, Dalia, Monzani, Silvia, Catalano, Irene, Grassi, Elena, Zanella, Eugenia R., Botrugno, Oronza A., Morelli, Leonardo, Panina Bordignon, Paola, Caravagna, Giulio, Bertotti, Andrea, Martino, Gianvito, Aldrighetti, Luca, Pasqualato, Sebastiano, Trusolino, Livio, Cittaro, Davide, Tonon, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2397 631/1647/2210/2211 631/337/2569 631/378/2183/2182 631/67/69 Agriculture Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cancer Chromatin Chromatin - genetics DNA probes Drug resistance Epigenesis, Genetic - genetics Epigenetics Euchromatin Euchromatin - genetics Gene mapping Genomics Heterochromatin Heterochromatin - genetics Histones Humans Life Sciences Lysine Organoids Stem cells Transcription factors Transposase Transposases - genetics Velocity Xenografts Xenotransplantation
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