A multiscale study of morphological changes in tendons following repeated cyclic loading
The response of white New Zealand rabbit Achilles tendons to load was assessed using mechanical measures and confocal arthroscopy (CA). The progression of fatigue-loading-induced damage of the macro- (tenocyte morphology, fiber anisotropy and waviness), as well as the mechanical profile, were assess...
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| Veröffentlicht in: | Journal of biomechanics 2021-11, Vol.128, p.110790-110790, Article 110790 |
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| container_title | Journal of biomechanics |
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| creator | Al Makhzoomi, Anas K. Kirk, Thomas B. Allison, Garry T. |
| description | The response of white New Zealand rabbit Achilles tendons to load was assessed using mechanical measures and confocal arthroscopy (CA). The progression of fatigue-loading-induced damage of the macro- (tenocyte morphology, fiber anisotropy and waviness), as well as the mechanical profile, were assessed within the same non-viable intact tendon in response to prolonged cyclic and static loading (up to four hours) at different strain levels (3%, 6% and 9%). Strain-mediated repeated loading induced a significant decline in mechanical function (p |
| doi_str_mv | 10.1016/j.jbiomech.2021.110790 |
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The progression of fatigue-loading-induced damage of the macro- (tenocyte morphology, fiber anisotropy and waviness), as well as the mechanical profile, were assessed within the same non-viable intact tendon in response to prolonged cyclic and static loading (up to four hours) at different strain levels (3%, 6% and 9%). Strain-mediated repeated loading induced a significant decline in mechanical function (p < 0.05) with increased strain and cycles. Mechanical and structural resilience was lost with repeated loading (p < 0.05) at macroscales. The lengthening of D-periodicity correlated strongly with the overall tendon mechanical changes and loss of spindle shape in tenocytes. This is the first study to provide a clear concurrent assessment of form (morphology) and function (mechanics) of tendons undergoing different strain-mediated repeated loading at multiple-scale assessments. This study identifies a variety of multiscale properties that may contribute to the understanding of mechanisms of tendon pathology.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2021.110790</identifier><identifier>PMID: 34634539</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Achilles Tendon ; Animals ; Anisotropy ; Arthroscopy ; Atomic force microscopy ; Collagen ; Concurrent nanostructural, macrostructural and mechanical assessment ; Confocal arthroscopy ; Cyclic loads ; Fatigue failure ; Force transmission in tendons ; Histology ; Investigations ; Load ; Mechanical properties ; Microscopy ; Morphology ; Periodicity ; Rabbits ; Repeated loading ; Strain ; Stress, Mechanical ; Tendon structure-function relationships ; Tendons ; Waviness</subject><ispartof>Journal of biomechanics, 2021-11, Vol.128, p.110790-110790, Article 110790</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. 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Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-3bfbe77f29f93377d1b5c568596a1bf0251ab9927d460131e7b8e8d4c3a528f63</citedby><cites>FETCH-LOGICAL-c396t-3bfbe77f29f93377d1b5c568596a1bf0251ab9927d460131e7b8e8d4c3a528f63</cites><orcidid>0000-0002-2430-6376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021929021005534$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34634539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al Makhzoomi, Anas K.</creatorcontrib><creatorcontrib>Kirk, Thomas B.</creatorcontrib><creatorcontrib>Allison, Garry T.</creatorcontrib><title>A multiscale study of morphological changes in tendons following repeated cyclic loading</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>The response of white New Zealand rabbit Achilles tendons to load was assessed using mechanical measures and confocal arthroscopy (CA). The progression of fatigue-loading-induced damage of the macro- (tenocyte morphology, fiber anisotropy and waviness), as well as the mechanical profile, were assessed within the same non-viable intact tendon in response to prolonged cyclic and static loading (up to four hours) at different strain levels (3%, 6% and 9%). Strain-mediated repeated loading induced a significant decline in mechanical function (p < 0.05) with increased strain and cycles. Mechanical and structural resilience was lost with repeated loading (p < 0.05) at macroscales. The lengthening of D-periodicity correlated strongly with the overall tendon mechanical changes and loss of spindle shape in tenocytes. This is the first study to provide a clear concurrent assessment of form (morphology) and function (mechanics) of tendons undergoing different strain-mediated repeated loading at multiple-scale assessments. This study identifies a variety of multiscale properties that may contribute to the understanding of mechanisms of tendon pathology.</description><subject>Achilles Tendon</subject><subject>Animals</subject><subject>Anisotropy</subject><subject>Arthroscopy</subject><subject>Atomic force microscopy</subject><subject>Collagen</subject><subject>Concurrent nanostructural, macrostructural and mechanical assessment</subject><subject>Confocal arthroscopy</subject><subject>Cyclic loads</subject><subject>Fatigue failure</subject><subject>Force transmission in tendons</subject><subject>Histology</subject><subject>Investigations</subject><subject>Load</subject><subject>Mechanical properties</subject><subject>Microscopy</subject><subject>Morphology</subject><subject>Periodicity</subject><subject>Rabbits</subject><subject>Repeated loading</subject><subject>Strain</subject><subject>Stress, Mechanical</subject><subject>Tendon structure-function 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multiscale study of morphological changes in tendons following repeated cyclic loading</title><author>Al Makhzoomi, Anas K. ; Kirk, Thomas B. ; Allison, Garry T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-3bfbe77f29f93377d1b5c568596a1bf0251ab9927d460131e7b8e8d4c3a528f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Achilles Tendon</topic><topic>Animals</topic><topic>Anisotropy</topic><topic>Arthroscopy</topic><topic>Atomic force microscopy</topic><topic>Collagen</topic><topic>Concurrent nanostructural, macrostructural and mechanical assessment</topic><topic>Confocal arthroscopy</topic><topic>Cyclic loads</topic><topic>Fatigue failure</topic><topic>Force transmission in tendons</topic><topic>Histology</topic><topic>Investigations</topic><topic>Load</topic><topic>Mechanical properties</topic><topic>Microscopy</topic><topic>Morphology</topic><topic>Periodicity</topic><topic>Rabbits</topic><topic>Repeated loading</topic><topic>Strain</topic><topic>Stress, Mechanical</topic><topic>Tendon structure-function relationships</topic><topic>Tendons</topic><topic>Waviness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al Makhzoomi, Anas K.</creatorcontrib><creatorcontrib>Kirk, Thomas B.</creatorcontrib><creatorcontrib>Allison, Garry T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education 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Biomech</addtitle><date>2021-11-09</date><risdate>2021</risdate><volume>128</volume><spage>110790</spage><epage>110790</epage><pages>110790-110790</pages><artnum>110790</artnum><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>The response of white New Zealand rabbit Achilles tendons to load was assessed using mechanical measures and confocal arthroscopy (CA). The progression of fatigue-loading-induced damage of the macro- (tenocyte morphology, fiber anisotropy and waviness), as well as the mechanical profile, were assessed within the same non-viable intact tendon in response to prolonged cyclic and static loading (up to four hours) at different strain levels (3%, 6% and 9%). Strain-mediated repeated loading induced a significant decline in mechanical function (p < 0.05) with increased strain and cycles. Mechanical and structural resilience was lost with repeated loading (p < 0.05) at macroscales. The lengthening of D-periodicity correlated strongly with the overall tendon mechanical changes and loss of spindle shape in tenocytes. This is the first study to provide a clear concurrent assessment of form (morphology) and function (mechanics) of tendons undergoing different strain-mediated repeated loading at multiple-scale assessments. This study identifies a variety of multiscale properties that may contribute to the understanding of mechanisms of tendon pathology.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>34634539</pmid><doi>10.1016/j.jbiomech.2021.110790</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2430-6376</orcidid></addata></record> |
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| ispartof | Journal of biomechanics, 2021-11, Vol.128, p.110790-110790, Article 110790 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Achilles Tendon Animals Anisotropy Arthroscopy Atomic force microscopy Collagen Concurrent nanostructural, macrostructural and mechanical assessment Confocal arthroscopy Cyclic loads Fatigue failure Force transmission in tendons Histology Investigations Load Mechanical properties Microscopy Morphology Periodicity Rabbits Repeated loading Strain Stress, Mechanical Tendon structure-function relationships Tendons Waviness |
| title | A multiscale study of morphological changes in tendons following repeated cyclic loading |
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