The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors
Thyroglobulin (Tg) measurement in fine-needle aspiration (FNA-Tg) has proved to be an excellent tool to identify metastatic cervical lymph nodes (CLN) before or after surgery for papillary thyroid cancer (PTC). The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of...
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Veröffentlicht in: | Surgical oncology 2021-12, Vol.39, p.101666-101666, Article 101666 |
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creator | Wang, Yuxuan Duan, Yuansheng Zhou, Mengqian Liu, Jin Lai, Qingchuan Ye, Beibei Liu, Dandan Li, Linqi Fang, Yan Yue, Kai Jing, Chao Wu, Yansheng Wang, Xudong |
description | Thyroglobulin (Tg) measurement in fine-needle aspiration (FNA-Tg) has proved to be an excellent tool to identify metastatic cervical lymph nodes (CLN) before or after surgery for papillary thyroid cancer (PTC). The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of ultrasound (US) and fine-needle aspiration cytology (FNAC), especially for small or cystic LN. The combination of FNAC and FNA-Tg can provide nearly 100% diagnostic sensitivity and specificity for CLN metastasis. However, the cutoff values of FNA-Tg for metastatic CLN have not been standardized, and the reported cutoff values of FNA-Tg range from 0.2 ng/ml to 77 ng/ml because of the differences in study samples, Tg measurement methods, Tg assays kits, etc. Serum anti-thyroglobulin antibody level, serum thyroglobulin level, the presence or absence of thyroid glands, and the characteristics of CLN may be factors affecting the accuracy of FNA-Tg. This review summarizes the recent research on the application of FNA-Tg in the diagnosis of metastatic LN in PTC and provides a reliable basis for the clinical diagnosis of cervical lymph node metastasis.
•High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future. |
doi_str_mv | 10.1016/j.suronc.2021.101666 |
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•High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future.</description><identifier>ISSN: 0960-7404</identifier><identifier>EISSN: 1879-3320</identifier><identifier>DOI: 10.1016/j.suronc.2021.101666</identifier><identifier>PMID: 34634575</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Accuracy ; Antibodies ; Biomarkers, Tumor - blood ; Biopsy, Fine-Needle ; Cancer ; Cellular biology ; Cytology ; Diagnosis ; Fine-needle aspiration ; Humans ; Laboratories ; Lymph Node Excision ; Lymph nodes ; Lymphatic Metastasis - diagnosis ; Lymphatic system ; Measurement methods ; Medical prognosis ; Metastases ; Metastasis ; Papillary thyroid cancer ; Papillary thyroid carcinoma ; Patients ; Sensitivity and Specificity ; Surgery ; Thyroglobulin ; Thyroglobulin - blood ; Thyroid ; Thyroid cancer ; Thyroid Cancer, Papillary - blood ; Ultrasound</subject><ispartof>Surgical oncology, 2021-12, Vol.39, p.101666-101666, Article 101666</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Dec 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-c17a7e336dba36486388614888f18244db63fe6f04dc9025f8218e3604904fcd3</citedby><cites>FETCH-LOGICAL-c390t-c17a7e336dba36486388614888f18244db63fe6f04dc9025f8218e3604904fcd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960740421001559$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34634575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yuxuan</creatorcontrib><creatorcontrib>Duan, Yuansheng</creatorcontrib><creatorcontrib>Zhou, Mengqian</creatorcontrib><creatorcontrib>Liu, Jin</creatorcontrib><creatorcontrib>Lai, Qingchuan</creatorcontrib><creatorcontrib>Ye, Beibei</creatorcontrib><creatorcontrib>Liu, Dandan</creatorcontrib><creatorcontrib>Li, Linqi</creatorcontrib><creatorcontrib>Fang, Yan</creatorcontrib><creatorcontrib>Yue, Kai</creatorcontrib><creatorcontrib>Jing, Chao</creatorcontrib><creatorcontrib>Wu, Yansheng</creatorcontrib><creatorcontrib>Wang, Xudong</creatorcontrib><title>The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors</title><title>Surgical oncology</title><addtitle>Surg Oncol</addtitle><description>Thyroglobulin (Tg) measurement in fine-needle aspiration (FNA-Tg) has proved to be an excellent tool to identify metastatic cervical lymph nodes (CLN) before or after surgery for papillary thyroid cancer (PTC). The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of ultrasound (US) and fine-needle aspiration cytology (FNAC), especially for small or cystic LN. The combination of FNAC and FNA-Tg can provide nearly 100% diagnostic sensitivity and specificity for CLN metastasis. However, the cutoff values of FNA-Tg for metastatic CLN have not been standardized, and the reported cutoff values of FNA-Tg range from 0.2 ng/ml to 77 ng/ml because of the differences in study samples, Tg measurement methods, Tg assays kits, etc. Serum anti-thyroglobulin antibody level, serum thyroglobulin level, the presence or absence of thyroid glands, and the characteristics of CLN may be factors affecting the accuracy of FNA-Tg. This review summarizes the recent research on the application of FNA-Tg in the diagnosis of metastatic LN in PTC and provides a reliable basis for the clinical diagnosis of cervical lymph node metastasis.
•High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future.</description><subject>Accuracy</subject><subject>Antibodies</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biopsy, Fine-Needle</subject><subject>Cancer</subject><subject>Cellular biology</subject><subject>Cytology</subject><subject>Diagnosis</subject><subject>Fine-needle aspiration</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Lymph Node Excision</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic system</subject><subject>Measurement methods</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Papillary thyroid cancer</subject><subject>Papillary thyroid carcinoma</subject><subject>Patients</subject><subject>Sensitivity and Specificity</subject><subject>Surgery</subject><subject>Thyroglobulin</subject><subject>Thyroglobulin - blood</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary - blood</subject><subject>Ultrasound</subject><issn>0960-7404</issn><issn>1879-3320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhQtRnHb0DUQCbtxUm79KpTaCDDoKA27GdUgnN9NpqpIySY300_iqpqZGFy6EQMjlO-fe3NM0rwneE0zE-9M-LykGs6eYkoeSEE-aHZH90DJG8dNmhweB255jftG8yPmEMRY9Jc-bC8YF413f7Zpft0dA1uu7EHPxBt3rcQEUHSrHc4p3Yzwsow-oHucDtAHAjoB0nn3SxcewohMUnYte5eN5mo8oRAt51cy1CKFk9NOXY33Nfhx1Om_m3iKjg4GEdLDIl1XhavdQvB6R06bElF82z5weM7x6vC-b758_3V59aW--XX-9-njTGjbg0hrS6x4YE_agmeBSMCkF4VJKRyTl3B4EcyAc5tYMmHZOUiKBCcwHzJ2x7LJ5t_nOKf5YIBc1-WygjhsgLlnRThIqsRxERd_-g57ikkKdTlGBxYCHjpJK8Y0yKeacwKk5-al-XhGs1rTUSW0BqjVAtQVYZW8ezZfDBPav6E9iFfiwAVC3ce8hqWzqjg1Yn8AUZaP_f4ff2SOwsg</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Wang, Yuxuan</creator><creator>Duan, Yuansheng</creator><creator>Zhou, Mengqian</creator><creator>Liu, Jin</creator><creator>Lai, Qingchuan</creator><creator>Ye, Beibei</creator><creator>Liu, Dandan</creator><creator>Li, Linqi</creator><creator>Fang, Yan</creator><creator>Yue, Kai</creator><creator>Jing, Chao</creator><creator>Wu, Yansheng</creator><creator>Wang, Xudong</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors</title><author>Wang, Yuxuan ; Duan, Yuansheng ; Zhou, Mengqian ; Liu, Jin ; Lai, Qingchuan ; Ye, Beibei ; Liu, Dandan ; Li, Linqi ; Fang, Yan ; Yue, Kai ; Jing, Chao ; Wu, Yansheng ; Wang, Xudong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c17a7e336dba36486388614888f18244db63fe6f04dc9025f8218e3604904fcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Accuracy</topic><topic>Antibodies</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biopsy, Fine-Needle</topic><topic>Cancer</topic><topic>Cellular biology</topic><topic>Cytology</topic><topic>Diagnosis</topic><topic>Fine-needle aspiration</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Lymph Node Excision</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Lymphatic system</topic><topic>Measurement methods</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Papillary thyroid cancer</topic><topic>Papillary thyroid carcinoma</topic><topic>Patients</topic><topic>Sensitivity and Specificity</topic><topic>Surgery</topic><topic>Thyroglobulin</topic><topic>Thyroglobulin - blood</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid Cancer, Papillary - blood</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yuxuan</creatorcontrib><creatorcontrib>Duan, Yuansheng</creatorcontrib><creatorcontrib>Zhou, Mengqian</creatorcontrib><creatorcontrib>Liu, Jin</creatorcontrib><creatorcontrib>Lai, Qingchuan</creatorcontrib><creatorcontrib>Ye, Beibei</creatorcontrib><creatorcontrib>Liu, Dandan</creatorcontrib><creatorcontrib>Li, Linqi</creatorcontrib><creatorcontrib>Fang, Yan</creatorcontrib><creatorcontrib>Yue, Kai</creatorcontrib><creatorcontrib>Jing, Chao</creatorcontrib><creatorcontrib>Wu, Yansheng</creatorcontrib><creatorcontrib>Wang, Xudong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yuxuan</au><au>Duan, Yuansheng</au><au>Zhou, Mengqian</au><au>Liu, Jin</au><au>Lai, Qingchuan</au><au>Ye, Beibei</au><au>Liu, Dandan</au><au>Li, Linqi</au><au>Fang, Yan</au><au>Yue, Kai</au><au>Jing, Chao</au><au>Wu, Yansheng</au><au>Wang, Xudong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors</atitle><jtitle>Surgical oncology</jtitle><addtitle>Surg Oncol</addtitle><date>2021-12</date><risdate>2021</risdate><volume>39</volume><spage>101666</spage><epage>101666</epage><pages>101666-101666</pages><artnum>101666</artnum><issn>0960-7404</issn><eissn>1879-3320</eissn><abstract>Thyroglobulin (Tg) measurement in fine-needle aspiration (FNA-Tg) has proved to be an excellent tool to identify metastatic cervical lymph nodes (CLN) before or after surgery for papillary thyroid cancer (PTC). The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of ultrasound (US) and fine-needle aspiration cytology (FNAC), especially for small or cystic LN. The combination of FNAC and FNA-Tg can provide nearly 100% diagnostic sensitivity and specificity for CLN metastasis. However, the cutoff values of FNA-Tg for metastatic CLN have not been standardized, and the reported cutoff values of FNA-Tg range from 0.2 ng/ml to 77 ng/ml because of the differences in study samples, Tg measurement methods, Tg assays kits, etc. Serum anti-thyroglobulin antibody level, serum thyroglobulin level, the presence or absence of thyroid glands, and the characteristics of CLN may be factors affecting the accuracy of FNA-Tg. This review summarizes the recent research on the application of FNA-Tg in the diagnosis of metastatic LN in PTC and provides a reliable basis for the clinical diagnosis of cervical lymph node metastasis.
•High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>34634575</pmid><doi>10.1016/j.suronc.2021.101666</doi><tpages>1</tpages></addata></record> |
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subjects | Accuracy Antibodies Biomarkers, Tumor - blood Biopsy, Fine-Needle Cancer Cellular biology Cytology Diagnosis Fine-needle aspiration Humans Laboratories Lymph Node Excision Lymph nodes Lymphatic Metastasis - diagnosis Lymphatic system Measurement methods Medical prognosis Metastases Metastasis Papillary thyroid cancer Papillary thyroid carcinoma Patients Sensitivity and Specificity Surgery Thyroglobulin Thyroglobulin - blood Thyroid Thyroid cancer Thyroid Cancer, Papillary - blood Ultrasound |
title | The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors |
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