The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors

Thyroglobulin (Tg) measurement in fine-needle aspiration (FNA-Tg) has proved to be an excellent tool to identify metastatic cervical lymph nodes (CLN) before or after surgery for papillary thyroid cancer (PTC). The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of...

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Veröffentlicht in:Surgical oncology 2021-12, Vol.39, p.101666-101666, Article 101666
Hauptverfasser: Wang, Yuxuan, Duan, Yuansheng, Zhou, Mengqian, Liu, Jin, Lai, Qingchuan, Ye, Beibei, Liu, Dandan, Li, Linqi, Fang, Yan, Yue, Kai, Jing, Chao, Wu, Yansheng, Wang, Xudong
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container_end_page 101666
container_issue
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container_title Surgical oncology
container_volume 39
creator Wang, Yuxuan
Duan, Yuansheng
Zhou, Mengqian
Liu, Jin
Lai, Qingchuan
Ye, Beibei
Liu, Dandan
Li, Linqi
Fang, Yan
Yue, Kai
Jing, Chao
Wu, Yansheng
Wang, Xudong
description Thyroglobulin (Tg) measurement in fine-needle aspiration (FNA-Tg) has proved to be an excellent tool to identify metastatic cervical lymph nodes (CLN) before or after surgery for papillary thyroid cancer (PTC). The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of ultrasound (US) and fine-needle aspiration cytology (FNAC), especially for small or cystic LN. The combination of FNAC and FNA-Tg can provide nearly 100% diagnostic sensitivity and specificity for CLN metastasis. However, the cutoff values of FNA-Tg for metastatic CLN have not been standardized, and the reported cutoff values of FNA-Tg range from 0.2 ng/ml to 77 ng/ml because of the differences in study samples, Tg measurement methods, Tg assays kits, etc. Serum anti-thyroglobulin antibody level, serum thyroglobulin level, the presence or absence of thyroid glands, and the characteristics of CLN may be factors affecting the accuracy of FNA-Tg. This review summarizes the recent research on the application of FNA-Tg in the diagnosis of metastatic LN in PTC and provides a reliable basis for the clinical diagnosis of cervical lymph node metastasis. •High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future.
doi_str_mv 10.1016/j.suronc.2021.101666
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The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of ultrasound (US) and fine-needle aspiration cytology (FNAC), especially for small or cystic LN. The combination of FNAC and FNA-Tg can provide nearly 100% diagnostic sensitivity and specificity for CLN metastasis. However, the cutoff values of FNA-Tg for metastatic CLN have not been standardized, and the reported cutoff values of FNA-Tg range from 0.2 ng/ml to 77 ng/ml because of the differences in study samples, Tg measurement methods, Tg assays kits, etc. Serum anti-thyroglobulin antibody level, serum thyroglobulin level, the presence or absence of thyroid glands, and the characteristics of CLN may be factors affecting the accuracy of FNA-Tg. This review summarizes the recent research on the application of FNA-Tg in the diagnosis of metastatic LN in PTC and provides a reliable basis for the clinical diagnosis of cervical lymph node metastasis. •High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future.</description><identifier>ISSN: 0960-7404</identifier><identifier>EISSN: 1879-3320</identifier><identifier>DOI: 10.1016/j.suronc.2021.101666</identifier><identifier>PMID: 34634575</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Accuracy ; Antibodies ; Biomarkers, Tumor - blood ; Biopsy, Fine-Needle ; Cancer ; Cellular biology ; Cytology ; Diagnosis ; Fine-needle aspiration ; Humans ; Laboratories ; Lymph Node Excision ; Lymph nodes ; Lymphatic Metastasis - diagnosis ; Lymphatic system ; Measurement methods ; Medical prognosis ; Metastases ; Metastasis ; Papillary thyroid cancer ; Papillary thyroid carcinoma ; Patients ; Sensitivity and Specificity ; Surgery ; Thyroglobulin ; Thyroglobulin - blood ; Thyroid ; Thyroid cancer ; Thyroid Cancer, Papillary - blood ; Ultrasound</subject><ispartof>Surgical oncology, 2021-12, Vol.39, p.101666-101666, Article 101666</ispartof><rights>2021</rights><rights>Copyright © 2021. 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This review summarizes the recent research on the application of FNA-Tg in the diagnosis of metastatic LN in PTC and provides a reliable basis for the clinical diagnosis of cervical lymph node metastasis. •High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future.</description><subject>Accuracy</subject><subject>Antibodies</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biopsy, Fine-Needle</subject><subject>Cancer</subject><subject>Cellular biology</subject><subject>Cytology</subject><subject>Diagnosis</subject><subject>Fine-needle aspiration</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Lymph Node Excision</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic system</subject><subject>Measurement methods</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Papillary thyroid cancer</subject><subject>Papillary thyroid carcinoma</subject><subject>Patients</subject><subject>Sensitivity and Specificity</subject><subject>Surgery</subject><subject>Thyroglobulin</subject><subject>Thyroglobulin - blood</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary - blood</subject><subject>Ultrasound</subject><issn>0960-7404</issn><issn>1879-3320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhQtRnHb0DUQCbtxUm79KpTaCDDoKA27GdUgnN9NpqpIySY300_iqpqZGFy6EQMjlO-fe3NM0rwneE0zE-9M-LykGs6eYkoeSEE-aHZH90DJG8dNmhweB255jftG8yPmEMRY9Jc-bC8YF413f7Zpft0dA1uu7EHPxBt3rcQEUHSrHc4p3Yzwsow-oHucDtAHAjoB0nn3SxcewohMUnYte5eN5mo8oRAt51cy1CKFk9NOXY33Nfhx1Om_m3iKjg4GEdLDIl1XhavdQvB6R06bElF82z5weM7x6vC-b758_3V59aW--XX-9-njTGjbg0hrS6x4YE_agmeBSMCkF4VJKRyTl3B4EcyAc5tYMmHZOUiKBCcwHzJ2x7LJ5t_nOKf5YIBc1-WygjhsgLlnRThIqsRxERd_-g57ikkKdTlGBxYCHjpJK8Y0yKeacwKk5-al-XhGs1rTUSW0BqjVAtQVYZW8ezZfDBPav6E9iFfiwAVC3ce8hqWzqjg1Yn8AUZaP_f4ff2SOwsg</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Wang, Yuxuan</creator><creator>Duan, Yuansheng</creator><creator>Zhou, Mengqian</creator><creator>Liu, Jin</creator><creator>Lai, Qingchuan</creator><creator>Ye, Beibei</creator><creator>Liu, Dandan</creator><creator>Li, Linqi</creator><creator>Fang, Yan</creator><creator>Yue, Kai</creator><creator>Jing, Chao</creator><creator>Wu, Yansheng</creator><creator>Wang, Xudong</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors</title><author>Wang, Yuxuan ; 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The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of ultrasound (US) and fine-needle aspiration cytology (FNAC), especially for small or cystic LN. The combination of FNAC and FNA-Tg can provide nearly 100% diagnostic sensitivity and specificity for CLN metastasis. However, the cutoff values of FNA-Tg for metastatic CLN have not been standardized, and the reported cutoff values of FNA-Tg range from 0.2 ng/ml to 77 ng/ml because of the differences in study samples, Tg measurement methods, Tg assays kits, etc. Serum anti-thyroglobulin antibody level, serum thyroglobulin level, the presence or absence of thyroid glands, and the characteristics of CLN may be factors affecting the accuracy of FNA-Tg. This review summarizes the recent research on the application of FNA-Tg in the diagnosis of metastatic LN in PTC and provides a reliable basis for the clinical diagnosis of cervical lymph node metastasis. •High-titer FNA-Tg strongly supports the presence of CLNM.•The diagnostic value of FNA-Tg combine FNAC could reach to 100%.•Each laboratory should choose its own cutoff values to suit its needs.•FNA-Tg is a quantitative index, final diagnosis is based on postoperative pathology.•More prospective studies should be conducted in the future.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>34634575</pmid><doi>10.1016/j.suronc.2021.101666</doi><tpages>1</tpages></addata></record>
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subjects Accuracy
Antibodies
Biomarkers, Tumor - blood
Biopsy, Fine-Needle
Cancer
Cellular biology
Cytology
Diagnosis
Fine-needle aspiration
Humans
Laboratories
Lymph Node Excision
Lymph nodes
Lymphatic Metastasis - diagnosis
Lymphatic system
Measurement methods
Medical prognosis
Metastases
Metastasis
Papillary thyroid cancer
Papillary thyroid carcinoma
Patients
Sensitivity and Specificity
Surgery
Thyroglobulin
Thyroglobulin - blood
Thyroid
Thyroid cancer
Thyroid Cancer, Papillary - blood
Ultrasound
title The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors
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